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HPV-negative and HPV-positive HNSCC cell lines show similar numerical but different structural chromosomal aberrations

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HPV-negative and HPV-positive HNSCC cell lines show similar numerical but different structural chromosomal aberrations. / Arenz, Andrea; Patze, Johannes; Kornmann, Evelyn; Wilhelm, Jochen; Ziemann, Frank; Wagner, Steffen; Wittig, Andrea; Schoetz, Ulrike; Engenhart-Cabillic, Rita; Dikomey, Ekkehard; Fritz, Barbara.

In: HEAD NECK-J SCI SPEC, Vol. 41, No. 11, 11.2019, p. 3869-3879.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Arenz, A, Patze, J, Kornmann, E, Wilhelm, J, Ziemann, F, Wagner, S, Wittig, A, Schoetz, U, Engenhart-Cabillic, R, Dikomey, E & Fritz, B 2019, 'HPV-negative and HPV-positive HNSCC cell lines show similar numerical but different structural chromosomal aberrations', HEAD NECK-J SCI SPEC, vol. 41, no. 11, pp. 3869-3879. https://doi.org/10.1002/hed.25924

APA

Arenz, A., Patze, J., Kornmann, E., Wilhelm, J., Ziemann, F., Wagner, S., Wittig, A., Schoetz, U., Engenhart-Cabillic, R., Dikomey, E., & Fritz, B. (2019). HPV-negative and HPV-positive HNSCC cell lines show similar numerical but different structural chromosomal aberrations. HEAD NECK-J SCI SPEC, 41(11), 3869-3879. https://doi.org/10.1002/hed.25924

Vancouver

Arenz A, Patze J, Kornmann E, Wilhelm J, Ziemann F, Wagner S et al. HPV-negative and HPV-positive HNSCC cell lines show similar numerical but different structural chromosomal aberrations. HEAD NECK-J SCI SPEC. 2019 Nov;41(11):3869-3879. https://doi.org/10.1002/hed.25924

Bibtex

@article{6cd7cf19708f4889bf351b6b6f6b88b3,
title = "HPV-negative and HPV-positive HNSCC cell lines show similar numerical but different structural chromosomal aberrations",
abstract = "BACKGROUND: It was tested whether the difference in carcinogenesis between noxa and human papillomavirus (HPV)-driven head and neck squamous cell carcinoma (HNSCC) is associated with a variation in genomic instability.METHODS: Conventional and molecular cytogenetics in HPV-positive and HPV-negative HNSCC cell lines.RESULTS: Numerical aneuploidy determined by multicolor fluorescence in situ hybridization and DNA ploidy was very similar for both entities with most chromosomes being present either in quadruplicate or triplicate, and only few are still diploid with, however, a striking similarity in the overall pattern. A clear difference was seen concerning the translocations formed, with no difference in the total amount but with a significantly higher genomic instability of HPV-positive cell lines at chromosome 3 as compared to HPV-negative cells.CONCLUSION: The different processes of carcinogenesis of HPV-positive and HPV-negative HNSCC appear to result in a similar pattern of numerical but a clear difference in structural chromosomal aberrations.",
author = "Andrea Arenz and Johannes Patze and Evelyn Kornmann and Jochen Wilhelm and Frank Ziemann and Steffen Wagner and Andrea Wittig and Ulrike Schoetz and Rita Engenhart-Cabillic and Ekkehard Dikomey and Barbara Fritz",
note = "{\textcopyright} 2019 The Authors. Head & Neck published by Wiley Periodicals, Inc.",
year = "2019",
month = nov,
doi = "10.1002/hed.25924",
language = "English",
volume = "41",
pages = "3869--3879",
journal = "HEAD NECK-J SCI SPEC",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - HPV-negative and HPV-positive HNSCC cell lines show similar numerical but different structural chromosomal aberrations

AU - Arenz, Andrea

AU - Patze, Johannes

AU - Kornmann, Evelyn

AU - Wilhelm, Jochen

AU - Ziemann, Frank

AU - Wagner, Steffen

AU - Wittig, Andrea

AU - Schoetz, Ulrike

AU - Engenhart-Cabillic, Rita

AU - Dikomey, Ekkehard

AU - Fritz, Barbara

N1 - © 2019 The Authors. Head & Neck published by Wiley Periodicals, Inc.

PY - 2019/11

Y1 - 2019/11

N2 - BACKGROUND: It was tested whether the difference in carcinogenesis between noxa and human papillomavirus (HPV)-driven head and neck squamous cell carcinoma (HNSCC) is associated with a variation in genomic instability.METHODS: Conventional and molecular cytogenetics in HPV-positive and HPV-negative HNSCC cell lines.RESULTS: Numerical aneuploidy determined by multicolor fluorescence in situ hybridization and DNA ploidy was very similar for both entities with most chromosomes being present either in quadruplicate or triplicate, and only few are still diploid with, however, a striking similarity in the overall pattern. A clear difference was seen concerning the translocations formed, with no difference in the total amount but with a significantly higher genomic instability of HPV-positive cell lines at chromosome 3 as compared to HPV-negative cells.CONCLUSION: The different processes of carcinogenesis of HPV-positive and HPV-negative HNSCC appear to result in a similar pattern of numerical but a clear difference in structural chromosomal aberrations.

AB - BACKGROUND: It was tested whether the difference in carcinogenesis between noxa and human papillomavirus (HPV)-driven head and neck squamous cell carcinoma (HNSCC) is associated with a variation in genomic instability.METHODS: Conventional and molecular cytogenetics in HPV-positive and HPV-negative HNSCC cell lines.RESULTS: Numerical aneuploidy determined by multicolor fluorescence in situ hybridization and DNA ploidy was very similar for both entities with most chromosomes being present either in quadruplicate or triplicate, and only few are still diploid with, however, a striking similarity in the overall pattern. A clear difference was seen concerning the translocations formed, with no difference in the total amount but with a significantly higher genomic instability of HPV-positive cell lines at chromosome 3 as compared to HPV-negative cells.CONCLUSION: The different processes of carcinogenesis of HPV-positive and HPV-negative HNSCC appear to result in a similar pattern of numerical but a clear difference in structural chromosomal aberrations.

U2 - 10.1002/hed.25924

DO - 10.1002/hed.25924

M3 - SCORING: Journal article

C2 - 31441163

VL - 41

SP - 3869

EP - 3879

JO - HEAD NECK-J SCI SPEC

JF - HEAD NECK-J SCI SPEC

SN - 1043-3074

IS - 11

ER -