HMGB1: a two-headed signal regulating tumor progression and immunity
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HMGB1: a two-headed signal regulating tumor progression and immunity. / Campana, L.; Bosurgi, L.; Rovere-Querini, P.
In: CURR OPIN IMMUNOL, Vol. 20, No. 5, 2008, p. 518-523.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - HMGB1: a two-headed signal regulating tumor progression and immunity
AU - Campana, L.
AU - Bosurgi, L.
AU - Rovere-Querini, P.
PY - 2008
Y1 - 2008
N2 - Cells of the innate immune system sense tissue damage recognizing in the extracellular environment bona fide intracellular moieties, like high mobility group box 1 (HMGB1). In the case of tumors, HMGB1 recognition has a paradoxical dual effect: it promotes tumor neoangiogenesis and triggers protective anti-neoplastic T-cell responses. Recent advances in the study of HMGB1 have identified candidate molecular mechanisms underlying these apparently contrasting outcomes. A surprising role for innate receptors, including toll like receptor 4 (TLR4), in the response to conventional cancer radio and chemotherapy has also recently emerged, providing new insight into the mechanisms by which these treatments actually work.
AB - Cells of the innate immune system sense tissue damage recognizing in the extracellular environment bona fide intracellular moieties, like high mobility group box 1 (HMGB1). In the case of tumors, HMGB1 recognition has a paradoxical dual effect: it promotes tumor neoangiogenesis and triggers protective anti-neoplastic T-cell responses. Recent advances in the study of HMGB1 have identified candidate molecular mechanisms underlying these apparently contrasting outcomes. A surprising role for innate receptors, including toll like receptor 4 (TLR4), in the response to conventional cancer radio and chemotherapy has also recently emerged, providing new insight into the mechanisms by which these treatments actually work.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-50549094596&partnerID=MN8TOARS
U2 - 10.1016/j.coi.2008.04.012
DO - 10.1016/j.coi.2008.04.012
M3 - SCORING: Review article
C2 - 18599281
VL - 20
SP - 518
EP - 523
IS - 5
ER -