Histology and Serum Cytokine Responses in an Imported Infection, Germany
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Histology and Serum Cytokine Responses in an Imported Infection, Germany. / Tappe, Dennis; Booken, Nina; Böer-Auer, Almut; Rauch, Jessica; Schmiedel, Stefan; Reich, Kristian.
In: AM J TROP MED HYG, Vol. 98, No. 1, 01.2018, p. 248-251.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Histology and Serum Cytokine Responses in an Imported Infection, Germany
AU - Tappe, Dennis
AU - Booken, Nina
AU - Böer-Auer, Almut
AU - Rauch, Jessica
AU - Schmiedel, Stefan
AU - Reich, Kristian
PY - 2018/1
Y1 - 2018/1
N2 - Rickettsia slovaca, a spotted fever group rickettsial pathogen, causes a syndrome consisting of scalp eschar and neck lymphadenopathy following tick bite. We analyzed the histologic skin reaction in the eschar, showing a prominent eosinophilic infiltration, as well as the presence of B lymphocytes and CD4- and CD8-positive T cells. Examination of the serum cytokine responses over time demonstrated an initial proinflammatory cytokine elevation followed by normalization.
AB - Rickettsia slovaca, a spotted fever group rickettsial pathogen, causes a syndrome consisting of scalp eschar and neck lymphadenopathy following tick bite. We analyzed the histologic skin reaction in the eschar, showing a prominent eosinophilic infiltration, as well as the presence of B lymphocytes and CD4- and CD8-positive T cells. Examination of the serum cytokine responses over time demonstrated an initial proinflammatory cytokine elevation followed by normalization.
KW - Cytokines
KW - Female
KW - France
KW - Germany
KW - Humans
KW - Lymphadenopathy
KW - Middle Aged
KW - Rickettsia
KW - Scalp
KW - Skin
KW - Spotted Fever Group Rickettsiosis
KW - Travel
KW - Journal Article
U2 - 10.4269/ajtmh.17-0392
DO - 10.4269/ajtmh.17-0392
M3 - SCORING: Journal article
C2 - 29141745
VL - 98
SP - 248
EP - 251
JO - AM J TROP MED HYG
JF - AM J TROP MED HYG
SN - 0002-9637
IS - 1
ER -