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High-sensitivity assays for troponin in patients with cardiac disease

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High-sensitivity assays for troponin in patients with cardiac disease. / Westermann, Dirk; Neumann, Johannes Tobias; Sörensen, Nils Arne; Blankenberg, Stefan.

In: NAT REV CARDIOL, Vol. 14, No. 8, 08.2017, p. 472-483.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Westermann, D, Neumann, JT, Sörensen, NA & Blankenberg, S 2017, 'High-sensitivity assays for troponin in patients with cardiac disease', NAT REV CARDIOL, vol. 14, no. 8, pp. 472-483. https://doi.org/10.1038/nrcardio.2017.48

APA

Westermann, D., Neumann, J. T., Sörensen, N. A., & Blankenberg, S. (2017). High-sensitivity assays for troponin in patients with cardiac disease. NAT REV CARDIOL, 14(8), 472-483. https://doi.org/10.1038/nrcardio.2017.48

Vancouver

Westermann D, Neumann JT, Sörensen NA, Blankenberg S. High-sensitivity assays for troponin in patients with cardiac disease. NAT REV CARDIOL. 2017 Aug;14(8):472-483. https://doi.org/10.1038/nrcardio.2017.48

Bibtex

@article{de11fe3583b14c71b6ea86b3e983c03a,
title = "High-sensitivity assays for troponin in patients with cardiac disease",
abstract = "Troponin is a widely used biomarker in patients with cardiac disease. The use of troponin is well established in patients with suspected acute myocardial infarction (AMI), but troponin measurement is also used in other acute and nonacute settings. In patients with suspected AMI, early decision-making is crucial to allow rapid treatment and further diagnostic evaluation. Current guidelines recommend serial measurements of troponin with a cut-off concentration at the 99th percentile to triage patients in the emergency department. Newer, high-sensitivity assays for troponin enable the detection of distinctly lower concentrations. Using these assays and very low cut-off concentrations, several rapid diagnostic strategies have been reported to improve diagnosis in acute cardiac care. Furthermore, noncoronary and nonacute applications of troponin assays - for example as a biomarker in patients with heart failure, pulmonary embolism, or stable coronary artery disease - are on the horizon and might improve individual risk stratification. In this Review, we provide an overview on the development of high-sensitivity assays for troponin, and their application in patients with cardiac disease.",
keywords = "Biomarkers/blood, Blood Chemical Analysis/methods, Heart Diseases/diagnosis, Humans, Myocardial Infarction/diagnosis, Sensitivity and Specificity, Troponin/blood",
author = "Dirk Westermann and Neumann, {Johannes Tobias} and S{\"o}rensen, {Nils Arne} and Stefan Blankenberg",
year = "2017",
month = aug,
doi = "10.1038/nrcardio.2017.48",
language = "English",
volume = "14",
pages = "472--483",
journal = "NAT REV CARDIOL",
issn = "1759-5002",
publisher = "NATURE PUBLISHING GROUP",
number = "8",

}

RIS

TY - JOUR

T1 - High-sensitivity assays for troponin in patients with cardiac disease

AU - Westermann, Dirk

AU - Neumann, Johannes Tobias

AU - Sörensen, Nils Arne

AU - Blankenberg, Stefan

PY - 2017/8

Y1 - 2017/8

N2 - Troponin is a widely used biomarker in patients with cardiac disease. The use of troponin is well established in patients with suspected acute myocardial infarction (AMI), but troponin measurement is also used in other acute and nonacute settings. In patients with suspected AMI, early decision-making is crucial to allow rapid treatment and further diagnostic evaluation. Current guidelines recommend serial measurements of troponin with a cut-off concentration at the 99th percentile to triage patients in the emergency department. Newer, high-sensitivity assays for troponin enable the detection of distinctly lower concentrations. Using these assays and very low cut-off concentrations, several rapid diagnostic strategies have been reported to improve diagnosis in acute cardiac care. Furthermore, noncoronary and nonacute applications of troponin assays - for example as a biomarker in patients with heart failure, pulmonary embolism, or stable coronary artery disease - are on the horizon and might improve individual risk stratification. In this Review, we provide an overview on the development of high-sensitivity assays for troponin, and their application in patients with cardiac disease.

AB - Troponin is a widely used biomarker in patients with cardiac disease. The use of troponin is well established in patients with suspected acute myocardial infarction (AMI), but troponin measurement is also used in other acute and nonacute settings. In patients with suspected AMI, early decision-making is crucial to allow rapid treatment and further diagnostic evaluation. Current guidelines recommend serial measurements of troponin with a cut-off concentration at the 99th percentile to triage patients in the emergency department. Newer, high-sensitivity assays for troponin enable the detection of distinctly lower concentrations. Using these assays and very low cut-off concentrations, several rapid diagnostic strategies have been reported to improve diagnosis in acute cardiac care. Furthermore, noncoronary and nonacute applications of troponin assays - for example as a biomarker in patients with heart failure, pulmonary embolism, or stable coronary artery disease - are on the horizon and might improve individual risk stratification. In this Review, we provide an overview on the development of high-sensitivity assays for troponin, and their application in patients with cardiac disease.

KW - Biomarkers/blood

KW - Blood Chemical Analysis/methods

KW - Heart Diseases/diagnosis

KW - Humans

KW - Myocardial Infarction/diagnosis

KW - Sensitivity and Specificity

KW - Troponin/blood

U2 - 10.1038/nrcardio.2017.48

DO - 10.1038/nrcardio.2017.48

M3 - SCORING: Review article

C2 - 28383022

VL - 14

SP - 472

EP - 483

JO - NAT REV CARDIOL

JF - NAT REV CARDIOL

SN - 1759-5002

IS - 8

ER -