High-sensitivity assays for troponin in patients with cardiac disease
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High-sensitivity assays for troponin in patients with cardiac disease. / Westermann, Dirk; Neumann, Johannes Tobias; Sörensen, Nils Arne; Blankenberg, Stefan.
in: NAT REV CARDIOL, Jahrgang 14, Nr. 8, 08.2017, S. 472-483.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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T1 - High-sensitivity assays for troponin in patients with cardiac disease
AU - Westermann, Dirk
AU - Neumann, Johannes Tobias
AU - Sörensen, Nils Arne
AU - Blankenberg, Stefan
PY - 2017/8
Y1 - 2017/8
N2 - Troponin is a widely used biomarker in patients with cardiac disease. The use of troponin is well established in patients with suspected acute myocardial infarction (AMI), but troponin measurement is also used in other acute and nonacute settings. In patients with suspected AMI, early decision-making is crucial to allow rapid treatment and further diagnostic evaluation. Current guidelines recommend serial measurements of troponin with a cut-off concentration at the 99th percentile to triage patients in the emergency department. Newer, high-sensitivity assays for troponin enable the detection of distinctly lower concentrations. Using these assays and very low cut-off concentrations, several rapid diagnostic strategies have been reported to improve diagnosis in acute cardiac care. Furthermore, noncoronary and nonacute applications of troponin assays - for example as a biomarker in patients with heart failure, pulmonary embolism, or stable coronary artery disease - are on the horizon and might improve individual risk stratification. In this Review, we provide an overview on the development of high-sensitivity assays for troponin, and their application in patients with cardiac disease.
AB - Troponin is a widely used biomarker in patients with cardiac disease. The use of troponin is well established in patients with suspected acute myocardial infarction (AMI), but troponin measurement is also used in other acute and nonacute settings. In patients with suspected AMI, early decision-making is crucial to allow rapid treatment and further diagnostic evaluation. Current guidelines recommend serial measurements of troponin with a cut-off concentration at the 99th percentile to triage patients in the emergency department. Newer, high-sensitivity assays for troponin enable the detection of distinctly lower concentrations. Using these assays and very low cut-off concentrations, several rapid diagnostic strategies have been reported to improve diagnosis in acute cardiac care. Furthermore, noncoronary and nonacute applications of troponin assays - for example as a biomarker in patients with heart failure, pulmonary embolism, or stable coronary artery disease - are on the horizon and might improve individual risk stratification. In this Review, we provide an overview on the development of high-sensitivity assays for troponin, and their application in patients with cardiac disease.
KW - Biomarkers/blood
KW - Blood Chemical Analysis/methods
KW - Heart Diseases/diagnosis
KW - Humans
KW - Myocardial Infarction/diagnosis
KW - Sensitivity and Specificity
KW - Troponin/blood
U2 - 10.1038/nrcardio.2017.48
DO - 10.1038/nrcardio.2017.48
M3 - SCORING: Review article
C2 - 28383022
VL - 14
SP - 472
EP - 483
JO - NAT REV CARDIOL
JF - NAT REV CARDIOL
SN - 1759-5002
IS - 8
ER -