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High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains

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High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains. / Schwabenland, Marius; Hasavci, Dilara; Frase, Sibylle; Wolf, Katharina; Deigendesch, Nikolaus; Buescher, Joerg M; Mertz, Kirsten D; Ondruschka, Benjamin; Altmeppen, Hermann; Matschke, Jakob; Glatzel, Markus; Frank, Stephan; Thimme, Robert; Beck, Juergen; Hosp, Jonas A; Blank, Thomas; Bengsch, Bertram; Prinz, Marco.

In: ACTA NEUROPATHOL, Vol. 148, No. 1, 25.07.2024, p. 11.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schwabenland, M, Hasavci, D, Frase, S, Wolf, K, Deigendesch, N, Buescher, JM, Mertz, KD, Ondruschka, B, Altmeppen, H, Matschke, J, Glatzel, M, Frank, S, Thimme, R, Beck, J, Hosp, JA, Blank, T, Bengsch, B & Prinz, M 2024, 'High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains', ACTA NEUROPATHOL, vol. 148, no. 1, pp. 11. https://doi.org/10.1007/s00401-024-02770-6

APA

Schwabenland, M., Hasavci, D., Frase, S., Wolf, K., Deigendesch, N., Buescher, J. M., Mertz, K. D., Ondruschka, B., Altmeppen, H., Matschke, J., Glatzel, M., Frank, S., Thimme, R., Beck, J., Hosp, J. A., Blank, T., Bengsch, B., & Prinz, M. (2024). High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains. ACTA NEUROPATHOL, 148(1), 11. https://doi.org/10.1007/s00401-024-02770-6

Vancouver

Schwabenland M, Hasavci D, Frase S, Wolf K, Deigendesch N, Buescher JM et al. High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains. ACTA NEUROPATHOL. 2024 Jul 25;148(1):11. https://doi.org/10.1007/s00401-024-02770-6

Bibtex

@article{e61cfc44e8604bdd802216adc89e8a53,
title = "High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains",
abstract = "The underlying pathogenesis of neurological sequelae in post-COVID-19 patients remains unclear. Here, we used multidimensional spatial immune phenotyping and machine learning methods on brains from initial COVID-19 survivors to identify the biological correlate associated with previous SARS-CoV-2 challenge. Compared to healthy controls, individuals with post-COVID-19 revealed a high percentage of TMEM119+P2RY12+CD68+Iba1+HLA-DR+CD11c+SCAMP2+ microglia assembled in prototypical cellular nodules. In contrast to acute SARS-CoV-2 cases, the frequency of CD8+ parenchymal T cells was reduced, suggesting an immune shift toward innate immune activation that may contribute to neurological alterations in post-COVID-19 patients.",
keywords = "Humans, COVID-19/immunology, Immunity, Innate/immunology, Brain/immunology, Male, Female, Middle Aged, Aged, Microglia/immunology, Adult, CD8-Positive T-Lymphocytes/immunology, SARS-CoV-2/immunology, Cicatrix/immunology, Machine Learning",
author = "Marius Schwabenland and Dilara Hasavci and Sibylle Frase and Katharina Wolf and Nikolaus Deigendesch and Buescher, {Joerg M} and Mertz, {Kirsten D} and Benjamin Ondruschka and Hermann Altmeppen and Jakob Matschke and Markus Glatzel and Stephan Frank and Robert Thimme and Juergen Beck and Hosp, {Jonas A} and Thomas Blank and Bertram Bengsch and Marco Prinz",
note = "{\textcopyright} 2024. The Author(s).",
year = "2024",
month = jul,
day = "25",
doi = "10.1007/s00401-024-02770-6",
language = "English",
volume = "148",
pages = "11",
journal = "ACTA NEUROPATHOL",
issn = "0001-6322",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains

AU - Schwabenland, Marius

AU - Hasavci, Dilara

AU - Frase, Sibylle

AU - Wolf, Katharina

AU - Deigendesch, Nikolaus

AU - Buescher, Joerg M

AU - Mertz, Kirsten D

AU - Ondruschka, Benjamin

AU - Altmeppen, Hermann

AU - Matschke, Jakob

AU - Glatzel, Markus

AU - Frank, Stephan

AU - Thimme, Robert

AU - Beck, Juergen

AU - Hosp, Jonas A

AU - Blank, Thomas

AU - Bengsch, Bertram

AU - Prinz, Marco

N1 - © 2024. The Author(s).

PY - 2024/7/25

Y1 - 2024/7/25

N2 - The underlying pathogenesis of neurological sequelae in post-COVID-19 patients remains unclear. Here, we used multidimensional spatial immune phenotyping and machine learning methods on brains from initial COVID-19 survivors to identify the biological correlate associated with previous SARS-CoV-2 challenge. Compared to healthy controls, individuals with post-COVID-19 revealed a high percentage of TMEM119+P2RY12+CD68+Iba1+HLA-DR+CD11c+SCAMP2+ microglia assembled in prototypical cellular nodules. In contrast to acute SARS-CoV-2 cases, the frequency of CD8+ parenchymal T cells was reduced, suggesting an immune shift toward innate immune activation that may contribute to neurological alterations in post-COVID-19 patients.

AB - The underlying pathogenesis of neurological sequelae in post-COVID-19 patients remains unclear. Here, we used multidimensional spatial immune phenotyping and machine learning methods on brains from initial COVID-19 survivors to identify the biological correlate associated with previous SARS-CoV-2 challenge. Compared to healthy controls, individuals with post-COVID-19 revealed a high percentage of TMEM119+P2RY12+CD68+Iba1+HLA-DR+CD11c+SCAMP2+ microglia assembled in prototypical cellular nodules. In contrast to acute SARS-CoV-2 cases, the frequency of CD8+ parenchymal T cells was reduced, suggesting an immune shift toward innate immune activation that may contribute to neurological alterations in post-COVID-19 patients.

KW - Humans

KW - COVID-19/immunology

KW - Immunity, Innate/immunology

KW - Brain/immunology

KW - Male

KW - Female

KW - Middle Aged

KW - Aged

KW - Microglia/immunology

KW - Adult

KW - CD8-Positive T-Lymphocytes/immunology

KW - SARS-CoV-2/immunology

KW - Cicatrix/immunology

KW - Machine Learning

U2 - 10.1007/s00401-024-02770-6

DO - 10.1007/s00401-024-02770-6

M3 - SCORING: Journal article

C2 - 39060438

VL - 148

SP - 11

JO - ACTA NEUROPATHOL

JF - ACTA NEUROPATHOL

SN - 0001-6322

IS - 1

ER -