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High RNA-binding motif protein 3 expression is an independent prognostic marker in operated prostate cancer and tightly linked to ERG activation and PTEN deletions

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High RNA-binding motif protein 3 expression is an independent prognostic marker in operated prostate cancer and tightly linked to ERG activation and PTEN deletions. / Grupp, Katharina; Wilking, Julia; Prien, Kristina; Hube-Magg, Claudia; Sirma, Hüseyin; Simon, Ronald; Steurer, Stefan; Budäus, Lars; Haese, Alexander; Izbicki, Jakob; Sauter, Guido; Minner, Sarah; Schlomm, Thorsten; Tsourlakis, Maria Christina.

In: EUR J CANCER, Vol. 50, No. 4, 01.03.2014, p. 852-61.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Grupp, K, Wilking, J, Prien, K, Hube-Magg, C, Sirma, H, Simon, R, Steurer, S, Budäus, L, Haese, A, Izbicki, J, Sauter, G, Minner, S, Schlomm, T & Tsourlakis, MC 2014, 'High RNA-binding motif protein 3 expression is an independent prognostic marker in operated prostate cancer and tightly linked to ERG activation and PTEN deletions', EUR J CANCER, vol. 50, no. 4, pp. 852-61. https://doi.org/10.1016/j.ejca.2013.12.003

APA

Grupp, K., Wilking, J., Prien, K., Hube-Magg, C., Sirma, H., Simon, R., Steurer, S., Budäus, L., Haese, A., Izbicki, J., Sauter, G., Minner, S., Schlomm, T., & Tsourlakis, M. C. (2014). High RNA-binding motif protein 3 expression is an independent prognostic marker in operated prostate cancer and tightly linked to ERG activation and PTEN deletions. EUR J CANCER, 50(4), 852-61. https://doi.org/10.1016/j.ejca.2013.12.003

Vancouver

Grupp K, Wilking J, Prien K, Hube-Magg C, Sirma H, Simon R et al. High RNA-binding motif protein 3 expression is an independent prognostic marker in operated prostate cancer and tightly linked to ERG activation and PTEN deletions. EUR J CANCER. 2014 Mar 1;50(4):852-61. https://doi.org/10.1016/j.ejca.2013.12.003

Bibtex

@article{f701fe595ecd47e39a72357613eab562,
title = "High RNA-binding motif protein 3 expression is an independent prognostic marker in operated prostate cancer and tightly linked to ERG activation and PTEN deletions",
abstract = "BACKGROUND: The RNA-binding motif protein 3 (RBM3) has recently been suspected as a prognostic biomarker in several cancers.METHODS: RBM3 expression was analysed by immunohistochemistry on a tissue microarray containing 11,152 prostate cancers.RESULTS: RBM3 expression was more often detectable in malignant compared to benign prostate. RBM3 immunostaining was found in 64% of the interpretable prostate cancers and was considered strong in 25.6%. High RBM3 expression was linked to advanced tumour stage, high Gleason score, positive nodal involvement and positive surgical margin status (p<0.0001 each). There was a remarkable accumulation of strong RBM3 expression in v-ets avian erythroblastosis virus E26 oncogene homolog (ERG) positive prostate cancers and tumours harbouring PTEN deletions (p<0.0001 each). Moreover, RBM3 staining was tightly related to early biochemical recurrence if all tumours or subgroups of ERG negative and ERG positive cancers were analysed (p<0.0001 each). In multivariate analysis, including RBM3 staining, Gleason grade, pT stage, prostate-specific antigen (PSA), surgical margin status, and nodal status, the prognostic impact of RBM3 staining retained statistically significance (p=0.0084).CONCLUSION: Our observations indicate that high RBM3 expression is an independent prognostic marker in prostate cancer. The tight link to ERG activation and PTEN deletions suggest interaction with key molecular pathways in prostate cancer.",
keywords = "Adult, Aged, Aged, 80 and over, Gene Deletion, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, PTEN Phosphohydrolase, Prognosis, Prostatectomy, Prostatic Neoplasms, RNA-Binding Proteins, Trans-Activators, Transcriptional Activation, Tumor Markers, Biological",
author = "Katharina Grupp and Julia Wilking and Kristina Prien and Claudia Hube-Magg and H{\"u}seyin Sirma and Ronald Simon and Stefan Steurer and Lars Bud{\"a}us and Alexander Haese and Jakob Izbicki and Guido Sauter and Sarah Minner and Thorsten Schlomm and Tsourlakis, {Maria Christina}",
note = "Copyright {\textcopyright} 2013 Elsevier Ltd. All rights reserved.",
year = "2014",
month = mar,
day = "1",
doi = "10.1016/j.ejca.2013.12.003",
language = "English",
volume = "50",
pages = "852--61",
journal = "EUR J CANCER",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "4",

}

RIS

TY - JOUR

T1 - High RNA-binding motif protein 3 expression is an independent prognostic marker in operated prostate cancer and tightly linked to ERG activation and PTEN deletions

AU - Grupp, Katharina

AU - Wilking, Julia

AU - Prien, Kristina

AU - Hube-Magg, Claudia

AU - Sirma, Hüseyin

AU - Simon, Ronald

AU - Steurer, Stefan

AU - Budäus, Lars

AU - Haese, Alexander

AU - Izbicki, Jakob

AU - Sauter, Guido

AU - Minner, Sarah

AU - Schlomm, Thorsten

AU - Tsourlakis, Maria Christina

N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.

PY - 2014/3/1

Y1 - 2014/3/1

N2 - BACKGROUND: The RNA-binding motif protein 3 (RBM3) has recently been suspected as a prognostic biomarker in several cancers.METHODS: RBM3 expression was analysed by immunohistochemistry on a tissue microarray containing 11,152 prostate cancers.RESULTS: RBM3 expression was more often detectable in malignant compared to benign prostate. RBM3 immunostaining was found in 64% of the interpretable prostate cancers and was considered strong in 25.6%. High RBM3 expression was linked to advanced tumour stage, high Gleason score, positive nodal involvement and positive surgical margin status (p<0.0001 each). There was a remarkable accumulation of strong RBM3 expression in v-ets avian erythroblastosis virus E26 oncogene homolog (ERG) positive prostate cancers and tumours harbouring PTEN deletions (p<0.0001 each). Moreover, RBM3 staining was tightly related to early biochemical recurrence if all tumours or subgroups of ERG negative and ERG positive cancers were analysed (p<0.0001 each). In multivariate analysis, including RBM3 staining, Gleason grade, pT stage, prostate-specific antigen (PSA), surgical margin status, and nodal status, the prognostic impact of RBM3 staining retained statistically significance (p=0.0084).CONCLUSION: Our observations indicate that high RBM3 expression is an independent prognostic marker in prostate cancer. The tight link to ERG activation and PTEN deletions suggest interaction with key molecular pathways in prostate cancer.

AB - BACKGROUND: The RNA-binding motif protein 3 (RBM3) has recently been suspected as a prognostic biomarker in several cancers.METHODS: RBM3 expression was analysed by immunohistochemistry on a tissue microarray containing 11,152 prostate cancers.RESULTS: RBM3 expression was more often detectable in malignant compared to benign prostate. RBM3 immunostaining was found in 64% of the interpretable prostate cancers and was considered strong in 25.6%. High RBM3 expression was linked to advanced tumour stage, high Gleason score, positive nodal involvement and positive surgical margin status (p<0.0001 each). There was a remarkable accumulation of strong RBM3 expression in v-ets avian erythroblastosis virus E26 oncogene homolog (ERG) positive prostate cancers and tumours harbouring PTEN deletions (p<0.0001 each). Moreover, RBM3 staining was tightly related to early biochemical recurrence if all tumours or subgroups of ERG negative and ERG positive cancers were analysed (p<0.0001 each). In multivariate analysis, including RBM3 staining, Gleason grade, pT stage, prostate-specific antigen (PSA), surgical margin status, and nodal status, the prognostic impact of RBM3 staining retained statistically significance (p=0.0084).CONCLUSION: Our observations indicate that high RBM3 expression is an independent prognostic marker in prostate cancer. The tight link to ERG activation and PTEN deletions suggest interaction with key molecular pathways in prostate cancer.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Gene Deletion

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Male

KW - Middle Aged

KW - PTEN Phosphohydrolase

KW - Prognosis

KW - Prostatectomy

KW - Prostatic Neoplasms

KW - RNA-Binding Proteins

KW - Trans-Activators

KW - Transcriptional Activation

KW - Tumor Markers, Biological

U2 - 10.1016/j.ejca.2013.12.003

DO - 10.1016/j.ejca.2013.12.003

M3 - SCORING: Journal article

C2 - 24380696

VL - 50

SP - 852

EP - 861

JO - EUR J CANCER

JF - EUR J CANCER

SN - 0959-8049

IS - 4

ER -