High RNA-binding motif protein 3 expression is an independent prognostic marker in operated prostate cancer and tightly linked to ERG activation and PTEN deletions
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High RNA-binding motif protein 3 expression is an independent prognostic marker in operated prostate cancer and tightly linked to ERG activation and PTEN deletions. / Grupp, Katharina; Wilking, Julia; Prien, Kristina; Hube-Magg, Claudia; Sirma, Hüseyin; Simon, Ronald; Steurer, Stefan; Budäus, Lars; Haese, Alexander; Izbicki, Jakob; Sauter, Guido; Minner, Sarah; Schlomm, Thorsten; Tsourlakis, Maria Christina.
in: EUR J CANCER, Jahrgang 50, Nr. 4, 01.03.2014, S. 852-61.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - High RNA-binding motif protein 3 expression is an independent prognostic marker in operated prostate cancer and tightly linked to ERG activation and PTEN deletions
AU - Grupp, Katharina
AU - Wilking, Julia
AU - Prien, Kristina
AU - Hube-Magg, Claudia
AU - Sirma, Hüseyin
AU - Simon, Ronald
AU - Steurer, Stefan
AU - Budäus, Lars
AU - Haese, Alexander
AU - Izbicki, Jakob
AU - Sauter, Guido
AU - Minner, Sarah
AU - Schlomm, Thorsten
AU - Tsourlakis, Maria Christina
N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.
PY - 2014/3/1
Y1 - 2014/3/1
N2 - BACKGROUND: The RNA-binding motif protein 3 (RBM3) has recently been suspected as a prognostic biomarker in several cancers.METHODS: RBM3 expression was analysed by immunohistochemistry on a tissue microarray containing 11,152 prostate cancers.RESULTS: RBM3 expression was more often detectable in malignant compared to benign prostate. RBM3 immunostaining was found in 64% of the interpretable prostate cancers and was considered strong in 25.6%. High RBM3 expression was linked to advanced tumour stage, high Gleason score, positive nodal involvement and positive surgical margin status (p<0.0001 each). There was a remarkable accumulation of strong RBM3 expression in v-ets avian erythroblastosis virus E26 oncogene homolog (ERG) positive prostate cancers and tumours harbouring PTEN deletions (p<0.0001 each). Moreover, RBM3 staining was tightly related to early biochemical recurrence if all tumours or subgroups of ERG negative and ERG positive cancers were analysed (p<0.0001 each). In multivariate analysis, including RBM3 staining, Gleason grade, pT stage, prostate-specific antigen (PSA), surgical margin status, and nodal status, the prognostic impact of RBM3 staining retained statistically significance (p=0.0084).CONCLUSION: Our observations indicate that high RBM3 expression is an independent prognostic marker in prostate cancer. The tight link to ERG activation and PTEN deletions suggest interaction with key molecular pathways in prostate cancer.
AB - BACKGROUND: The RNA-binding motif protein 3 (RBM3) has recently been suspected as a prognostic biomarker in several cancers.METHODS: RBM3 expression was analysed by immunohistochemistry on a tissue microarray containing 11,152 prostate cancers.RESULTS: RBM3 expression was more often detectable in malignant compared to benign prostate. RBM3 immunostaining was found in 64% of the interpretable prostate cancers and was considered strong in 25.6%. High RBM3 expression was linked to advanced tumour stage, high Gleason score, positive nodal involvement and positive surgical margin status (p<0.0001 each). There was a remarkable accumulation of strong RBM3 expression in v-ets avian erythroblastosis virus E26 oncogene homolog (ERG) positive prostate cancers and tumours harbouring PTEN deletions (p<0.0001 each). Moreover, RBM3 staining was tightly related to early biochemical recurrence if all tumours or subgroups of ERG negative and ERG positive cancers were analysed (p<0.0001 each). In multivariate analysis, including RBM3 staining, Gleason grade, pT stage, prostate-specific antigen (PSA), surgical margin status, and nodal status, the prognostic impact of RBM3 staining retained statistically significance (p=0.0084).CONCLUSION: Our observations indicate that high RBM3 expression is an independent prognostic marker in prostate cancer. The tight link to ERG activation and PTEN deletions suggest interaction with key molecular pathways in prostate cancer.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Gene Deletion
KW - Gene Expression Regulation, Neoplastic
KW - Humans
KW - Male
KW - Middle Aged
KW - PTEN Phosphohydrolase
KW - Prognosis
KW - Prostatectomy
KW - Prostatic Neoplasms
KW - RNA-Binding Proteins
KW - Trans-Activators
KW - Transcriptional Activation
KW - Tumor Markers, Biological
U2 - 10.1016/j.ejca.2013.12.003
DO - 10.1016/j.ejca.2013.12.003
M3 - SCORING: Journal article
C2 - 24380696
VL - 50
SP - 852
EP - 861
JO - EUR J CANCER
JF - EUR J CANCER
SN - 0959-8049
IS - 4
ER -