High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.
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High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. / Kasprowicz, Victoria; Schulze Zur Wiesch, Julian; Kuntzen, Thomas; Nolan, Brian E; Longworth, Steven; Berical, Andrew; Blum, Jenna; McMahon, Cory; Reyor, Laura L; Elias, Nahel; Kwok, William W; McGovern, Barbara G; Freeman, Gordon; Chung, Raymond T; Klenerman, Paul; Lewis-Ximenez, Lia; Walker, Bruce D; Allen, Todd M; Kim, Arthur Y; Lauer, Georg M.
In: J VIROL, Vol. 82, No. 6, 6, 2008, p. 3154-3160.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.
AU - Kasprowicz, Victoria
AU - Schulze Zur Wiesch, Julian
AU - Kuntzen, Thomas
AU - Nolan, Brian E
AU - Longworth, Steven
AU - Berical, Andrew
AU - Blum, Jenna
AU - McMahon, Cory
AU - Reyor, Laura L
AU - Elias, Nahel
AU - Kwok, William W
AU - McGovern, Barbara G
AU - Freeman, Gordon
AU - Chung, Raymond T
AU - Klenerman, Paul
AU - Lewis-Ximenez, Lia
AU - Walker, Bruce D
AU - Allen, Todd M
AU - Kim, Arthur Y
AU - Lauer, Georg M
PY - 2008
Y1 - 2008
N2 - We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.
AB - We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.
M3 - SCORING: Zeitschriftenaufsatz
VL - 82
SP - 3154
EP - 3160
JO - J VIROL
JF - J VIROL
SN - 0022-538X
IS - 6
M1 - 6
ER -