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High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.

Standard

High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. / Kasprowicz, Victoria; Schulze Zur Wiesch, Julian; Kuntzen, Thomas; Nolan, Brian E; Longworth, Steven; Berical, Andrew; Blum, Jenna; McMahon, Cory; Reyor, Laura L; Elias, Nahel; Kwok, William W; McGovern, Barbara G; Freeman, Gordon; Chung, Raymond T; Klenerman, Paul; Lewis-Ximenez, Lia; Walker, Bruce D; Allen, Todd M; Kim, Arthur Y; Lauer, Georg M.

in: J VIROL, Jahrgang 82, Nr. 6, 6, 2008, S. 3154-3160.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kasprowicz, V, Schulze Zur Wiesch, J, Kuntzen, T, Nolan, BE, Longworth, S, Berical, A, Blum, J, McMahon, C, Reyor, LL, Elias, N, Kwok, WW, McGovern, BG, Freeman, G, Chung, RT, Klenerman, P, Lewis-Ximenez, L, Walker, BD, Allen, TM, Kim, AY & Lauer, GM 2008, 'High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.', J VIROL, Jg. 82, Nr. 6, 6, S. 3154-3160. <http://www.ncbi.nlm.nih.gov/pubmed/18160439?dopt=Citation>

APA

Kasprowicz, V., Schulze Zur Wiesch, J., Kuntzen, T., Nolan, B. E., Longworth, S., Berical, A., Blum, J., McMahon, C., Reyor, L. L., Elias, N., Kwok, W. W., McGovern, B. G., Freeman, G., Chung, R. T., Klenerman, P., Lewis-Ximenez, L., Walker, B. D., Allen, T. M., Kim, A. Y., & Lauer, G. M. (2008). High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. J VIROL, 82(6), 3154-3160. [6]. http://www.ncbi.nlm.nih.gov/pubmed/18160439?dopt=Citation

Vancouver

Kasprowicz V, Schulze Zur Wiesch J, Kuntzen T, Nolan BE, Longworth S, Berical A et al. High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. J VIROL. 2008;82(6):3154-3160. 6.

Bibtex

@article{b05f2b75888f427dbd6f0aee6c053f9b,
title = "High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.",
abstract = "We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.",
author = "Victoria Kasprowicz and {Schulze Zur Wiesch}, Julian and Thomas Kuntzen and Nolan, {Brian E} and Steven Longworth and Andrew Berical and Jenna Blum and Cory McMahon and Reyor, {Laura L} and Nahel Elias and Kwok, {William W} and McGovern, {Barbara G} and Gordon Freeman and Chung, {Raymond T} and Paul Klenerman and Lia Lewis-Ximenez and Walker, {Bruce D} and Allen, {Todd M} and Kim, {Arthur Y} and Lauer, {Georg M}",
year = "2008",
language = "Deutsch",
volume = "82",
pages = "3154--3160",
journal = "J VIROL",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "6",

}

RIS

TY - JOUR

T1 - High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.

AU - Kasprowicz, Victoria

AU - Schulze Zur Wiesch, Julian

AU - Kuntzen, Thomas

AU - Nolan, Brian E

AU - Longworth, Steven

AU - Berical, Andrew

AU - Blum, Jenna

AU - McMahon, Cory

AU - Reyor, Laura L

AU - Elias, Nahel

AU - Kwok, William W

AU - McGovern, Barbara G

AU - Freeman, Gordon

AU - Chung, Raymond T

AU - Klenerman, Paul

AU - Lewis-Ximenez, Lia

AU - Walker, Bruce D

AU - Allen, Todd M

AU - Kim, Arthur Y

AU - Lauer, Georg M

PY - 2008

Y1 - 2008

N2 - We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.

AB - We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.

M3 - SCORING: Zeitschriftenaufsatz

VL - 82

SP - 3154

EP - 3160

JO - J VIROL

JF - J VIROL

SN - 0022-538X

IS - 6

M1 - 6

ER -