High expression of class III β-tubulin in upper gastrointestinal cancer types
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High expression of class III β-tubulin in upper gastrointestinal cancer types. / Höflmayer, Doris; Öztürk, Eray; Schroeder, Cornelia; Hube-Magg, Claudia; Blessin, Niclas C; Simon, Ronald; Lang, Dagmar S; Neubauer, Emily; Göbel, Cosima; Heinrich, Marie-Christine; Fraune, Christoph; Möller, Katharina; Armbrust, Moritz; Freytag, Morton; Hinsch, Andrea; Lühr, Clara; Noack, Magdalena; Reiswich, Viktor; Weidemann, Sören; Bockhorn, Maximilian; Perez, Daniel; Izbicki, Jakob R; Sauter, Guido; Jacobsen, Frank.
In: ONCOL LETT, Vol. 16, No. 6, 12.2018, p. 7139-7145.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - High expression of class III β-tubulin in upper gastrointestinal cancer types
AU - Höflmayer, Doris
AU - Öztürk, Eray
AU - Schroeder, Cornelia
AU - Hube-Magg, Claudia
AU - Blessin, Niclas C
AU - Simon, Ronald
AU - Lang, Dagmar S
AU - Neubauer, Emily
AU - Göbel, Cosima
AU - Heinrich, Marie-Christine
AU - Fraune, Christoph
AU - Möller, Katharina
AU - Armbrust, Moritz
AU - Freytag, Morton
AU - Hinsch, Andrea
AU - Lühr, Clara
AU - Noack, Magdalena
AU - Reiswich, Viktor
AU - Weidemann, Sören
AU - Bockhorn, Maximilian
AU - Perez, Daniel
AU - Izbicki, Jakob R
AU - Sauter, Guido
AU - Jacobsen, Frank
PY - 2018/12
Y1 - 2018/12
N2 - Class III β-tubulin (TUBB3) is a component of microtubules of neuronal cells that is upregulated in various cancer entities. To better understand the role of TUBB3 in upper gastrointestinal tract cancer types, the present study assessed TUBB3 expression in tissue microarrays including 189 gastric and 428 esophageal cancer. TUBB3 expression was detected in 62.4% of gastric cancer, 73.8% of esophageal adenocarcinoma and 88.7% of esophageal squamous cell cancer, while control samples of normal esophageal and gastric epithelium were TUBB3-negative. TUBB3 positivity was not associated with the International Union Against Cancer classification, World Health Organization grading, lymph node involvement or distant metastasis in any entity. Of note, TUBB3 expression was associated with tumor localization and prognosis in gastric cancer, with the tumor stage in esophageal adenocarcinoma, and with the resection margin in esophageal squamous cell cancer. In conclusion, the substantial rate of positivity for TUBB3 already in early stages of gastric cancer in combination with the lack of a further increase in frequency with tumor stage, may suggest, that TUBB3 upregulation is rather relevant for cancer development than for cancer progression. TUBB3 might be a suitable prognostic biomarker in gastric cancer types.
AB - Class III β-tubulin (TUBB3) is a component of microtubules of neuronal cells that is upregulated in various cancer entities. To better understand the role of TUBB3 in upper gastrointestinal tract cancer types, the present study assessed TUBB3 expression in tissue microarrays including 189 gastric and 428 esophageal cancer. TUBB3 expression was detected in 62.4% of gastric cancer, 73.8% of esophageal adenocarcinoma and 88.7% of esophageal squamous cell cancer, while control samples of normal esophageal and gastric epithelium were TUBB3-negative. TUBB3 positivity was not associated with the International Union Against Cancer classification, World Health Organization grading, lymph node involvement or distant metastasis in any entity. Of note, TUBB3 expression was associated with tumor localization and prognosis in gastric cancer, with the tumor stage in esophageal adenocarcinoma, and with the resection margin in esophageal squamous cell cancer. In conclusion, the substantial rate of positivity for TUBB3 already in early stages of gastric cancer in combination with the lack of a further increase in frequency with tumor stage, may suggest, that TUBB3 upregulation is rather relevant for cancer development than for cancer progression. TUBB3 might be a suitable prognostic biomarker in gastric cancer types.
KW - Journal Article
U2 - 10.3892/ol.2018.9502
DO - 10.3892/ol.2018.9502
M3 - SCORING: Journal article
C2 - 30546449
VL - 16
SP - 7139
EP - 7145
JO - ONCOL LETT
JF - ONCOL LETT
SN - 1792-1074
IS - 6
ER -