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High expression of class III β-tubulin in upper gastrointestinal cancer types

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High expression of class III β-tubulin in upper gastrointestinal cancer types. / Höflmayer, Doris; Öztürk, Eray; Schroeder, Cornelia; Hube-Magg, Claudia; Blessin, Niclas C; Simon, Ronald; Lang, Dagmar S; Neubauer, Emily; Göbel, Cosima; Heinrich, Marie-Christine; Fraune, Christoph; Möller, Katharina; Armbrust, Moritz; Freytag, Morton; Hinsch, Andrea; Lühr, Clara; Noack, Magdalena; Reiswich, Viktor; Weidemann, Sören; Bockhorn, Maximilian; Perez, Daniel; Izbicki, Jakob R; Sauter, Guido; Jacobsen, Frank.

in: ONCOL LETT, Jahrgang 16, Nr. 6, 12.2018, S. 7139-7145.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Höflmayer, D, Öztürk, E, Schroeder, C, Hube-Magg, C, Blessin, NC, Simon, R, Lang, DS, Neubauer, E, Göbel, C, Heinrich, M-C, Fraune, C, Möller, K, Armbrust, M, Freytag, M, Hinsch, A, Lühr, C, Noack, M, Reiswich, V, Weidemann, S, Bockhorn, M, Perez, D, Izbicki, JR, Sauter, G & Jacobsen, F 2018, 'High expression of class III β-tubulin in upper gastrointestinal cancer types', ONCOL LETT, Jg. 16, Nr. 6, S. 7139-7145. https://doi.org/10.3892/ol.2018.9502

APA

Höflmayer, D., Öztürk, E., Schroeder, C., Hube-Magg, C., Blessin, N. C., Simon, R., Lang, D. S., Neubauer, E., Göbel, C., Heinrich, M-C., Fraune, C., Möller, K., Armbrust, M., Freytag, M., Hinsch, A., Lühr, C., Noack, M., Reiswich, V., Weidemann, S., ... Jacobsen, F. (2018). High expression of class III β-tubulin in upper gastrointestinal cancer types. ONCOL LETT, 16(6), 7139-7145. https://doi.org/10.3892/ol.2018.9502

Vancouver

Höflmayer D, Öztürk E, Schroeder C, Hube-Magg C, Blessin NC, Simon R et al. High expression of class III β-tubulin in upper gastrointestinal cancer types. ONCOL LETT. 2018 Dez;16(6):7139-7145. https://doi.org/10.3892/ol.2018.9502

Bibtex

@article{db194b965afd404bbdfe3ed482422cca,
title = "High expression of class III β-tubulin in upper gastrointestinal cancer types",
abstract = "Class III β-tubulin (TUBB3) is a component of microtubules of neuronal cells that is upregulated in various cancer entities. To better understand the role of TUBB3 in upper gastrointestinal tract cancer types, the present study assessed TUBB3 expression in tissue microarrays including 189 gastric and 428 esophageal cancer. TUBB3 expression was detected in 62.4% of gastric cancer, 73.8% of esophageal adenocarcinoma and 88.7% of esophageal squamous cell cancer, while control samples of normal esophageal and gastric epithelium were TUBB3-negative. TUBB3 positivity was not associated with the International Union Against Cancer classification, World Health Organization grading, lymph node involvement or distant metastasis in any entity. Of note, TUBB3 expression was associated with tumor localization and prognosis in gastric cancer, with the tumor stage in esophageal adenocarcinoma, and with the resection margin in esophageal squamous cell cancer. In conclusion, the substantial rate of positivity for TUBB3 already in early stages of gastric cancer in combination with the lack of a further increase in frequency with tumor stage, may suggest, that TUBB3 upregulation is rather relevant for cancer development than for cancer progression. TUBB3 might be a suitable prognostic biomarker in gastric cancer types.",
keywords = "Journal Article",
author = "Doris H{\"o}flmayer and Eray {\"O}zt{\"u}rk and Cornelia Schroeder and Claudia Hube-Magg and Blessin, {Niclas C} and Ronald Simon and Lang, {Dagmar S} and Emily Neubauer and Cosima G{\"o}bel and Marie-Christine Heinrich and Christoph Fraune and Katharina M{\"o}ller and Moritz Armbrust and Morton Freytag and Andrea Hinsch and Clara L{\"u}hr and Magdalena Noack and Viktor Reiswich and S{\"o}ren Weidemann and Maximilian Bockhorn and Daniel Perez and Izbicki, {Jakob R} and Guido Sauter and Frank Jacobsen",
year = "2018",
month = dec,
doi = "10.3892/ol.2018.9502",
language = "English",
volume = "16",
pages = "7139--7145",
journal = "ONCOL LETT",
issn = "1792-1074",
publisher = "Spandidos Publications",
number = "6",

}

RIS

TY - JOUR

T1 - High expression of class III β-tubulin in upper gastrointestinal cancer types

AU - Höflmayer, Doris

AU - Öztürk, Eray

AU - Schroeder, Cornelia

AU - Hube-Magg, Claudia

AU - Blessin, Niclas C

AU - Simon, Ronald

AU - Lang, Dagmar S

AU - Neubauer, Emily

AU - Göbel, Cosima

AU - Heinrich, Marie-Christine

AU - Fraune, Christoph

AU - Möller, Katharina

AU - Armbrust, Moritz

AU - Freytag, Morton

AU - Hinsch, Andrea

AU - Lühr, Clara

AU - Noack, Magdalena

AU - Reiswich, Viktor

AU - Weidemann, Sören

AU - Bockhorn, Maximilian

AU - Perez, Daniel

AU - Izbicki, Jakob R

AU - Sauter, Guido

AU - Jacobsen, Frank

PY - 2018/12

Y1 - 2018/12

N2 - Class III β-tubulin (TUBB3) is a component of microtubules of neuronal cells that is upregulated in various cancer entities. To better understand the role of TUBB3 in upper gastrointestinal tract cancer types, the present study assessed TUBB3 expression in tissue microarrays including 189 gastric and 428 esophageal cancer. TUBB3 expression was detected in 62.4% of gastric cancer, 73.8% of esophageal adenocarcinoma and 88.7% of esophageal squamous cell cancer, while control samples of normal esophageal and gastric epithelium were TUBB3-negative. TUBB3 positivity was not associated with the International Union Against Cancer classification, World Health Organization grading, lymph node involvement or distant metastasis in any entity. Of note, TUBB3 expression was associated with tumor localization and prognosis in gastric cancer, with the tumor stage in esophageal adenocarcinoma, and with the resection margin in esophageal squamous cell cancer. In conclusion, the substantial rate of positivity for TUBB3 already in early stages of gastric cancer in combination with the lack of a further increase in frequency with tumor stage, may suggest, that TUBB3 upregulation is rather relevant for cancer development than for cancer progression. TUBB3 might be a suitable prognostic biomarker in gastric cancer types.

AB - Class III β-tubulin (TUBB3) is a component of microtubules of neuronal cells that is upregulated in various cancer entities. To better understand the role of TUBB3 in upper gastrointestinal tract cancer types, the present study assessed TUBB3 expression in tissue microarrays including 189 gastric and 428 esophageal cancer. TUBB3 expression was detected in 62.4% of gastric cancer, 73.8% of esophageal adenocarcinoma and 88.7% of esophageal squamous cell cancer, while control samples of normal esophageal and gastric epithelium were TUBB3-negative. TUBB3 positivity was not associated with the International Union Against Cancer classification, World Health Organization grading, lymph node involvement or distant metastasis in any entity. Of note, TUBB3 expression was associated with tumor localization and prognosis in gastric cancer, with the tumor stage in esophageal adenocarcinoma, and with the resection margin in esophageal squamous cell cancer. In conclusion, the substantial rate of positivity for TUBB3 already in early stages of gastric cancer in combination with the lack of a further increase in frequency with tumor stage, may suggest, that TUBB3 upregulation is rather relevant for cancer development than for cancer progression. TUBB3 might be a suitable prognostic biomarker in gastric cancer types.

KW - Journal Article

U2 - 10.3892/ol.2018.9502

DO - 10.3892/ol.2018.9502

M3 - SCORING: Journal article

C2 - 30546449

VL - 16

SP - 7139

EP - 7145

JO - ONCOL LETT

JF - ONCOL LETT

SN - 1792-1074

IS - 6

ER -