Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution.
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Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution. / Kasprowicz, Victoria; Kang, Yu-Hoi; Lucas, Michaela; Schulze Zur Wiesch, Julian; Kuntzen, Thomas; Fleming, Vicki; Nolan, Brian E; Longworth, Steven; Berical, Andrew; Bengsch, Bertram; Thimme, Robert; Lewis-Ximenez, Lia; Allen, Todd M; Kim, Arthur Y; Klenerman, Paul; Lauer, Georg M.
In: J VIROL, Vol. 84, No. 3, 3, 2010, p. 1656-1663.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution.
AU - Kasprowicz, Victoria
AU - Kang, Yu-Hoi
AU - Lucas, Michaela
AU - Schulze Zur Wiesch, Julian
AU - Kuntzen, Thomas
AU - Fleming, Vicki
AU - Nolan, Brian E
AU - Longworth, Steven
AU - Berical, Andrew
AU - Bengsch, Bertram
AU - Thimme, Robert
AU - Lewis-Ximenez, Lia
AU - Allen, Todd M
AU - Kim, Arthur Y
AU - Klenerman, Paul
AU - Lauer, Georg M
PY - 2010
Y1 - 2010
N2 - Hepatitis C virus (HCV)-specific CD8(+) T cells in persistent HCV infection are low in frequency and paradoxically show a phenotype associated with controlled infections, expressing the memory marker CD127. We addressed to what extent this phenotype is dependent on the presence of cognate antigen. We analyzed virus-specific responses in acute and chronic HCV infections and sequenced autologous virus. We show that CD127 expression is associated with decreased antigenic stimulation after either viral clearance or viral variation. Our data indicate that most CD8 T-cell responses in chronic HCV infection do not target the circulating virus and that the appearance of HCV-specific CD127(+) T cells is driven by viral variation.
AB - Hepatitis C virus (HCV)-specific CD8(+) T cells in persistent HCV infection are low in frequency and paradoxically show a phenotype associated with controlled infections, expressing the memory marker CD127. We addressed to what extent this phenotype is dependent on the presence of cognate antigen. We analyzed virus-specific responses in acute and chronic HCV infections and sequenced autologous virus. We show that CD127 expression is associated with decreased antigenic stimulation after either viral clearance or viral variation. Our data indicate that most CD8 T-cell responses in chronic HCV infection do not target the circulating virus and that the appearance of HCV-specific CD127(+) T cells is driven by viral variation.
M3 - SCORING: Zeitschriftenaufsatz
VL - 84
SP - 1656
EP - 1663
JO - J VIROL
JF - J VIROL
SN - 0022-538X
IS - 3
M1 - 3
ER -