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Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution.

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Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution. / Kasprowicz, Victoria; Kang, Yu-Hoi; Lucas, Michaela; Schulze Zur Wiesch, Julian; Kuntzen, Thomas; Fleming, Vicki; Nolan, Brian E; Longworth, Steven; Berical, Andrew; Bengsch, Bertram; Thimme, Robert; Lewis-Ximenez, Lia; Allen, Todd M; Kim, Arthur Y; Klenerman, Paul; Lauer, Georg M.

in: J VIROL, Jahrgang 84, Nr. 3, 3, 2010, S. 1656-1663.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kasprowicz, V, Kang, Y-H, Lucas, M, Schulze Zur Wiesch, J, Kuntzen, T, Fleming, V, Nolan, BE, Longworth, S, Berical, A, Bengsch, B, Thimme, R, Lewis-Ximenez, L, Allen, TM, Kim, AY, Klenerman, P & Lauer, GM 2010, 'Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution.', J VIROL, Jg. 84, Nr. 3, 3, S. 1656-1663. <http://www.ncbi.nlm.nih.gov/pubmed/19906915?dopt=Citation>

APA

Kasprowicz, V., Kang, Y-H., Lucas, M., Schulze Zur Wiesch, J., Kuntzen, T., Fleming, V., Nolan, B. E., Longworth, S., Berical, A., Bengsch, B., Thimme, R., Lewis-Ximenez, L., Allen, T. M., Kim, A. Y., Klenerman, P., & Lauer, G. M. (2010). Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution. J VIROL, 84(3), 1656-1663. [3]. http://www.ncbi.nlm.nih.gov/pubmed/19906915?dopt=Citation

Vancouver

Kasprowicz V, Kang Y-H, Lucas M, Schulze Zur Wiesch J, Kuntzen T, Fleming V et al. Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution. J VIROL. 2010;84(3):1656-1663. 3.

Bibtex

@article{a518e87ab9c6402896ac7c32ff252431,
title = "Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution.",
abstract = "Hepatitis C virus (HCV)-specific CD8(+) T cells in persistent HCV infection are low in frequency and paradoxically show a phenotype associated with controlled infections, expressing the memory marker CD127. We addressed to what extent this phenotype is dependent on the presence of cognate antigen. We analyzed virus-specific responses in acute and chronic HCV infections and sequenced autologous virus. We show that CD127 expression is associated with decreased antigenic stimulation after either viral clearance or viral variation. Our data indicate that most CD8 T-cell responses in chronic HCV infection do not target the circulating virus and that the appearance of HCV-specific CD127(+) T cells is driven by viral variation.",
author = "Victoria Kasprowicz and Yu-Hoi Kang and Michaela Lucas and {Schulze Zur Wiesch}, Julian and Thomas Kuntzen and Vicki Fleming and Nolan, {Brian E} and Steven Longworth and Andrew Berical and Bertram Bengsch and Robert Thimme and Lia Lewis-Ximenez and Allen, {Todd M} and Kim, {Arthur Y} and Paul Klenerman and Lauer, {Georg M}",
year = "2010",
language = "Deutsch",
volume = "84",
pages = "1656--1663",
journal = "J VIROL",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "3",

}

RIS

TY - JOUR

T1 - Hepatitis C virus (HCV) sequence variation induces an HCV-specific T-cell phenotype analogous to spontaneous resolution.

AU - Kasprowicz, Victoria

AU - Kang, Yu-Hoi

AU - Lucas, Michaela

AU - Schulze Zur Wiesch, Julian

AU - Kuntzen, Thomas

AU - Fleming, Vicki

AU - Nolan, Brian E

AU - Longworth, Steven

AU - Berical, Andrew

AU - Bengsch, Bertram

AU - Thimme, Robert

AU - Lewis-Ximenez, Lia

AU - Allen, Todd M

AU - Kim, Arthur Y

AU - Klenerman, Paul

AU - Lauer, Georg M

PY - 2010

Y1 - 2010

N2 - Hepatitis C virus (HCV)-specific CD8(+) T cells in persistent HCV infection are low in frequency and paradoxically show a phenotype associated with controlled infections, expressing the memory marker CD127. We addressed to what extent this phenotype is dependent on the presence of cognate antigen. We analyzed virus-specific responses in acute and chronic HCV infections and sequenced autologous virus. We show that CD127 expression is associated with decreased antigenic stimulation after either viral clearance or viral variation. Our data indicate that most CD8 T-cell responses in chronic HCV infection do not target the circulating virus and that the appearance of HCV-specific CD127(+) T cells is driven by viral variation.

AB - Hepatitis C virus (HCV)-specific CD8(+) T cells in persistent HCV infection are low in frequency and paradoxically show a phenotype associated with controlled infections, expressing the memory marker CD127. We addressed to what extent this phenotype is dependent on the presence of cognate antigen. We analyzed virus-specific responses in acute and chronic HCV infections and sequenced autologous virus. We show that CD127 expression is associated with decreased antigenic stimulation after either viral clearance or viral variation. Our data indicate that most CD8 T-cell responses in chronic HCV infection do not target the circulating virus and that the appearance of HCV-specific CD127(+) T cells is driven by viral variation.

M3 - SCORING: Zeitschriftenaufsatz

VL - 84

SP - 1656

EP - 1663

JO - J VIROL

JF - J VIROL

SN - 0022-538X

IS - 3

M1 - 3

ER -