Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice.

Marc Lütgehetmann; Till Bornscheuer; Tassilo Volz; Lena Allweiss; Jan-Hendrick Bockmann; Jörg-Matthias Pollok; Ansgar W. Lohse; Joerg Petersen; Maura Dandri-Petersen

Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice.

Standard

Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice. / Lütgehetmann, Marc; Bornscheuer, Till; Volz, Tassilo ; Allweiss, Lena ; Bockmann, Jan-Hendrick; Pollok, Jörg-Matthias; Lohse, Ansgar W.; Petersen, Joerg; Dandri-Petersen, Maura.

In: GASTROENTEROLOGY, Vol. 140, No. 7, 7, 2011, p. 1-2, 2074-2083.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lütgehetmann, M, Bornscheuer, T, Volz, T , Allweiss, L , Bockmann, J-H, Pollok, J-M, Lohse, AW, Petersen, J & Dandri-Petersen, M 2011, 'Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice.', GASTROENTEROLOGY, vol. 140, no. 7, 7, pp. 1-2, 2074-2083. <http://www.ncbi.nlm.nih.gov/pubmed/21376046?dopt=Citation>

APA

Lütgehetmann, M., Bornscheuer, T., Volz, T., Allweiss, L., Bockmann, J-H., Pollok, J-M., Lohse, A. W., Petersen, J., & Dandri-Petersen, M. (2011). Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice. GASTROENTEROLOGY, 140(7), 1-2, 2074-2083. [7]. http://www.ncbi.nlm.nih.gov/pubmed/21376046?dopt=Citation

Vancouver

Lütgehetmann M, Bornscheuer T, Volz T , Allweiss L , Bockmann J-H, Pollok J-M et al. Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice. GASTROENTEROLOGY. 2011;140(7):1-2, 2074-2083. 7.

Bibtex

@article{e0dfc1ad19654c9db52d25e3854d0ace,

title = "Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice.",

abstract = "Interferon (IFN)-? therapy is not effective for most patients with chronic hepatitis B virus (HBV) infection for reasons that are not clear. We investigated whether HBV infection reduced IFN-?-mediated induction of antiviral defense mechanisms in human hepatocytes.",

keywords = "Animals, Humans, Immunohistochemistry, Time Factors, Disease Models, Animal, Mice, Reverse Transcriptase Polymerase Chain Reaction, Promoter Regions, Genetic, Mice, Transgenic, Gene Expression Regulation/drug effects, Mice, SCID, DNA, Viral/metabolism, Active Transport, Cell Nucleus, Albumins/genetics, Antiviral Agents/*administration & dosage, Guanine/administration & dosage/analogs & derivatives, Hepatitis B/diagnosis/*drug therapy/genetics, Hepatitis B virus/*drug effects/genetics/growth & development, Hepatocytes/*drug effects/metabolism/*transplantation, Interferon-alpha/*administration & dosage, Liver/*drug effects/metabolism/virology, RNA, Viral/metabolism, STAT1 Transcription Factor/genetics/metabolism, *Transplantation Chimera, Urokinase-Type Plasminogen Activator/genetics, Animals, Humans, Immunohistochemistry, Time Factors, Disease Models, Animal, Mice, Reverse Transcriptase Polymerase Chain Reaction, Promoter Regions, Genetic, Mice, Transgenic, Gene Expression Regulation/drug effects, Mice, SCID, DNA, Viral/metabolism, Active Transport, Cell Nucleus, Albumins/genetics, Antiviral Agents/*administration & dosage, Guanine/administration & dosage/analogs & derivatives, Hepatitis B/diagnosis/*drug therapy/genetics, Hepatitis B virus/*drug effects/genetics/growth & development, Hepatocytes/*drug effects/metabolism/*transplantation, Interferon-alpha/*administration & dosage, Liver/*drug effects/metabolism/virology, RNA, Viral/metabolism, STAT1 Transcription Factor/genetics/metabolism, *Transplantation Chimera, Urokinase-Type Plasminogen Activator/genetics",

author = "Marc L{\"u}tgehetmann and Till Bornscheuer and Tassilo Volz and Lena Allweiss and Jan-Hendrick Bockmann and J{\"o}rg-Matthias Pollok and Lohse, {Ansgar W.} and Joerg Petersen and Maura Dandri-Petersen",

year = "2011",

language = "English",

volume = "140",

pages = "1--2, 2074--2083",

journal = "GASTROENTEROLOGY",

issn = "0016-5085",

publisher = "W.B. Saunders Ltd",

number = "7",

}

RIS

TY - JOUR

T1 - Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice.

AU - Lütgehetmann, Marc

AU - Bornscheuer, Till

AU - Volz, Tassilo

AU - Allweiss, Lena

AU - Bockmann, Jan-Hendrick

AU - Pollok, Jörg-Matthias

AU - Lohse, Ansgar W.

AU - Petersen, Joerg

AU - Dandri-Petersen, Maura

PY - 2011

Y1 - 2011

N2 - Interferon (IFN)-? therapy is not effective for most patients with chronic hepatitis B virus (HBV) infection for reasons that are not clear. We investigated whether HBV infection reduced IFN-?-mediated induction of antiviral defense mechanisms in human hepatocytes.

AB - Interferon (IFN)-? therapy is not effective for most patients with chronic hepatitis B virus (HBV) infection for reasons that are not clear. We investigated whether HBV infection reduced IFN-?-mediated induction of antiviral defense mechanisms in human hepatocytes.

KW - Animals

KW - Humans

KW - Immunohistochemistry

KW - Time Factors

KW - Disease Models, Animal

KW - Mice

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Promoter Regions, Genetic

KW - Mice, Transgenic

KW - Gene Expression Regulation/drug effects

KW - Mice, SCID

KW - DNA, Viral/metabolism

KW - Active Transport, Cell Nucleus

KW - Albumins/genetics

KW - Antiviral Agents/administration & dosage

KW - Guanine/administration & dosage/analogs & derivatives

KW - Hepatitis B/diagnosis/drug therapy/genetics

KW - Hepatitis B virus/drug effects/genetics/growth & development

KW - Hepatocytes/drug effects/metabolism/transplantation

KW - Interferon-alpha/administration & dosage

KW - Liver/drug effects/metabolism/virology

KW - RNA, Viral/metabolism

KW - STAT1 Transcription Factor/genetics/metabolism

KW - Transplantation Chimera

KW - Urokinase-Type Plasminogen Activator/genetics