Hepatitis B virus limits response of human hepatocytes to interferon-α in chimeric mice.

Abstract

Interferon (IFN)-? therapy is not effective for most patients with chronic hepatitis B virus (HBV) infection for reasons that are not clear. We investigated whether HBV infection reduced IFN-?-mediated induction of antiviral defense mechanisms in human hepatocytes.

Bibliographical data

Original languageEnglish
Article number7
ISSN0016-5085
Publication statusPublished - 2011
pubmed 21376046