Hepatic vasculopathy and regenerative responses of the liver in fatal cases of COVID-19

  • Barbara Kaltschmidt (Shared first author)
  • Antonia D E Fitzek (Shared first author)
  • Julia Schaedler (Shared first author)
  • Christine Förster (Shared first author)
  • Christian Kaltschmidt
  • Thorsten Hansen
  • Fabian Steinfurth
  • Beatrice A Windmöller
  • Christian Pilger
  • Cihang Kong
  • Kashika Singh
  • Axel Nierhaus
  • Dominic Wichmann
  • Jan Sperhake
  • Klaus Püschel
  • Thomas Huser
  • Martin Krüger (Shared last author)
  • Simon C Robson (Shared last author)
  • Ludwig Wilkens (Shared last author)
  • Jan Schulte Am Esch (Shared last author)

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects the nasopharynx and lungs and causes coronavirus disease-2019 (COVID-19). It may impact the heart, brain, kidney, and liver.1 Although functional impairment of the liver has been correlated with worse clinical outcomes, little is known about the pathophysiology of hepatic injury and repair in COVID-19.2,3 Histologic evaluation has been limited to small numbers of COVID-19 cases with no control subjects2,4 and demonstrated largely heterogeneous patterns of pathology.2,3.

Bibliographical data

Original languageEnglish
ISSN1542-3565
DOIs
Publication statusPublished - 08.2021
PubMed 33516952