Health-related quality of life and psychological well-being in elderly patients with haemophilia.
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Health-related quality of life and psychological well-being in elderly patients with haemophilia. / Mackensen von, Sylvia; Gringeri, A; Siboni, S M; Mannucci, P M; Centres, Italian Association Of Haemophilia.
In: HAEMOPHILIA, Vol. 18, No. 3, 3, 2012, p. 345-352.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Health-related quality of life and psychological well-being in elderly patients with haemophilia.
AU - Mackensen von, Sylvia
AU - Gringeri, A
AU - Siboni, S M
AU - Mannucci, P M
AU - Centres, Italian Association Of Haemophilia
PY - 2012
Y1 - 2012
N2 - Many persons with severe haemophilia reach seniority thanks to effective treatment. There is no information on health-related quality of life (HRQoL) of these patients, who had lived for many years when regular replacement therapy was unavailable. Italian patients with severe haemophilia aged ?65 years born in the 1940s or earlier were compared with men without bleeding disorders matched for age and geography. HRQoL was assessed via generic and disease-specific questionnaires. Potential associations with concomitant illnesses, orthopaedic status, physical functioning, cognitive status and depression were evaluated. In addition, the newly adapted HRQoL questionnaire specific for elderly persons with haemophilia (Haem-A-QoL(Eldlery)) was psychometrically tested and validated. Thirty-nine patients, aged 65-78 years, were investigated, 33 with haemophilia A and six with haemophilia B, and compared to 43 controls, aged 65-79 years. Chronic blood borne viral infections, hypertension and arthropathy were more frequent in patients, whereas hypercholesterolemia and cardiovascular diseases were more frequent in controls. Psychometric characteristics of Haem-A-QoL(Elderly) showed good to excellent values for reliability and validity. HRQoL was worse in patients at EQ-VAS, WHOQOL-BREF and WHOQOL-Old. The highest impairments were found in patients by means of the haemophilia-specific Haem-A-QoL(Elderly) in such dimensions as 'physical activity & leisure', 'physical health' and 'view'. A poor orthopaedic status was negatively associated with HRQoL. Compared to age-matched controls elderly patients with haemophilia had an impaired HRQoL in association with their health status. The newly developed Haem-A-QoL(Elderly) proved to be a reliable and valid instrument for HRQoL assessment in elderly haemophilia patients.
AB - Many persons with severe haemophilia reach seniority thanks to effective treatment. There is no information on health-related quality of life (HRQoL) of these patients, who had lived for many years when regular replacement therapy was unavailable. Italian patients with severe haemophilia aged ?65 years born in the 1940s or earlier were compared with men without bleeding disorders matched for age and geography. HRQoL was assessed via generic and disease-specific questionnaires. Potential associations with concomitant illnesses, orthopaedic status, physical functioning, cognitive status and depression were evaluated. In addition, the newly adapted HRQoL questionnaire specific for elderly persons with haemophilia (Haem-A-QoL(Eldlery)) was psychometrically tested and validated. Thirty-nine patients, aged 65-78 years, were investigated, 33 with haemophilia A and six with haemophilia B, and compared to 43 controls, aged 65-79 years. Chronic blood borne viral infections, hypertension and arthropathy were more frequent in patients, whereas hypercholesterolemia and cardiovascular diseases were more frequent in controls. Psychometric characteristics of Haem-A-QoL(Elderly) showed good to excellent values for reliability and validity. HRQoL was worse in patients at EQ-VAS, WHOQOL-BREF and WHOQOL-Old. The highest impairments were found in patients by means of the haemophilia-specific Haem-A-QoL(Elderly) in such dimensions as 'physical activity & leisure', 'physical health' and 'view'. A poor orthopaedic status was negatively associated with HRQoL. Compared to age-matched controls elderly patients with haemophilia had an impaired HRQoL in association with their health status. The newly developed Haem-A-QoL(Elderly) proved to be a reliable and valid instrument for HRQoL assessment in elderly haemophilia patients.
KW - Comorbidity
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Activities of Daily Living
KW - Questionnaires
KW - Cross-Sectional Studies
KW - Retrospective Studies
KW - Case-Control Studies
KW - Italy
KW - Psychometrics
KW - Health Status
KW - Quality of Life
KW - Hemophilia A/physiopathology/psychology
KW - Hemophilia B/physiopathology/psychology
KW - Comorbidity
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Activities of Daily Living
KW - Questionnaires
KW - Cross-Sectional Studies
KW - Retrospective Studies
KW - Case-Control Studies
KW - Italy
KW - Psychometrics
KW - Health Status
KW - Quality of Life
KW - Hemophilia A/physiopathology/psychology
KW - Hemophilia B/physiopathology/psychology
M3 - SCORING: Journal article
VL - 18
SP - 345
EP - 352
JO - HAEMOPHILIA
JF - HAEMOPHILIA
SN - 1351-8216
IS - 3
M1 - 3
ER -
