Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft-host interaction
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Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft-host interaction. / Mirza, Nora; Zierhut, Manfred; Korn, Andreas; Bornemann, Antje; Vogel, Wichard; Schmid-Horch, Barbara; Bethge, Wolfgang A; Stevanović, Stefan; Salih, Helmut R; Kanz, Lothar; Rammensee, Hans-Georg; Haen, Sebastian P.
In: P NATL ACAD SCI USA, Vol. 113, No. 48, 29.11.2016, p. 13827-13832.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft-host interaction
AU - Mirza, Nora
AU - Zierhut, Manfred
AU - Korn, Andreas
AU - Bornemann, Antje
AU - Vogel, Wichard
AU - Schmid-Horch, Barbara
AU - Bethge, Wolfgang A
AU - Stevanović, Stefan
AU - Salih, Helmut R
AU - Kanz, Lothar
AU - Rammensee, Hans-Georg
AU - Haen, Sebastian P
PY - 2016/11/29
Y1 - 2016/11/29
N2 - Graft-versus-host disease (GVHD) represents the major nonrelapse complication of allogeneic hematopoietic cell transplantation. Although rare, the CNS and the eye can be affected. In this study, manifestation in the retina as part of the CNS and T-cell epitopes recognized by the allogeneic T cells were evaluated. In 2 of 6 patients with posttransplantation retina diseases and 6 of 22 patients without ocular symptoms, antigen-specific T-cell responses against retina-specific epitopes were observed. No genetic differences between donor and recipient could be identified indicating T-cell activation against self-antigens (graft versus self). Transplantation of a preexisting immunity and cross-reactivity with ubiquitous epitopes was excluded in family donors and healthy individuals. In summary, an immunological reaction against retina cells represents a mechanism of graft-versus-host interaction following hematopoietic cell transplantation.
AB - Graft-versus-host disease (GVHD) represents the major nonrelapse complication of allogeneic hematopoietic cell transplantation. Although rare, the CNS and the eye can be affected. In this study, manifestation in the retina as part of the CNS and T-cell epitopes recognized by the allogeneic T cells were evaluated. In 2 of 6 patients with posttransplantation retina diseases and 6 of 22 patients without ocular symptoms, antigen-specific T-cell responses against retina-specific epitopes were observed. No genetic differences between donor and recipient could be identified indicating T-cell activation against self-antigens (graft versus self). Transplantation of a preexisting immunity and cross-reactivity with ubiquitous epitopes was excluded in family donors and healthy individuals. In summary, an immunological reaction against retina cells represents a mechanism of graft-versus-host interaction following hematopoietic cell transplantation.
KW - Adult
KW - Aged
KW - Autoantigens/immunology
KW - Epitopes, T-Lymphocyte/immunology
KW - Female
KW - Graft vs Host Disease/etiology
KW - Hematopoietic Stem Cell Transplantation/adverse effects
KW - Humans
KW - Lymphocyte Activation/immunology
KW - Male
KW - Middle Aged
KW - Retinal Diseases/etiology
KW - T-Lymphocytes/immunology
KW - Transplantation, Homologous/adverse effects
U2 - 10.1073/pnas.1609118113
DO - 10.1073/pnas.1609118113
M3 - SCORING: Journal article
C2 - 27834728
VL - 113
SP - 13827
EP - 13832
JO - P NATL ACAD SCI USA
JF - P NATL ACAD SCI USA
SN - 0027-8424
IS - 48
ER -