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Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft-host interaction

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Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft-host interaction. / Mirza, Nora; Zierhut, Manfred; Korn, Andreas; Bornemann, Antje; Vogel, Wichard; Schmid-Horch, Barbara; Bethge, Wolfgang A; Stevanović, Stefan; Salih, Helmut R; Kanz, Lothar; Rammensee, Hans-Georg; Haen, Sebastian P.

in: P NATL ACAD SCI USA, Jahrgang 113, Nr. 48, 29.11.2016, S. 13827-13832.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mirza, N, Zierhut, M, Korn, A, Bornemann, A, Vogel, W, Schmid-Horch, B, Bethge, WA, Stevanović, S, Salih, HR, Kanz, L, Rammensee, H-G & Haen, SP 2016, 'Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft-host interaction', P NATL ACAD SCI USA, Jg. 113, Nr. 48, S. 13827-13832. https://doi.org/10.1073/pnas.1609118113

APA

Mirza, N., Zierhut, M., Korn, A., Bornemann, A., Vogel, W., Schmid-Horch, B., Bethge, W. A., Stevanović, S., Salih, H. R., Kanz, L., Rammensee, H-G., & Haen, S. P. (2016). Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft-host interaction. P NATL ACAD SCI USA, 113(48), 13827-13832. https://doi.org/10.1073/pnas.1609118113

Vancouver

Mirza N, Zierhut M, Korn A, Bornemann A, Vogel W, Schmid-Horch B et al. Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft-host interaction. P NATL ACAD SCI USA. 2016 Nov 29;113(48):13827-13832. https://doi.org/10.1073/pnas.1609118113

Bibtex

@article{05e572d939cf493c8d1867f81a15fa9b,
title = "Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft-host interaction",
abstract = "Graft-versus-host disease (GVHD) represents the major nonrelapse complication of allogeneic hematopoietic cell transplantation. Although rare, the CNS and the eye can be affected. In this study, manifestation in the retina as part of the CNS and T-cell epitopes recognized by the allogeneic T cells were evaluated. In 2 of 6 patients with posttransplantation retina diseases and 6 of 22 patients without ocular symptoms, antigen-specific T-cell responses against retina-specific epitopes were observed. No genetic differences between donor and recipient could be identified indicating T-cell activation against self-antigens (graft versus self). Transplantation of a preexisting immunity and cross-reactivity with ubiquitous epitopes was excluded in family donors and healthy individuals. In summary, an immunological reaction against retina cells represents a mechanism of graft-versus-host interaction following hematopoietic cell transplantation.",
keywords = "Adult, Aged, Autoantigens/immunology, Epitopes, T-Lymphocyte/immunology, Female, Graft vs Host Disease/etiology, Hematopoietic Stem Cell Transplantation/adverse effects, Humans, Lymphocyte Activation/immunology, Male, Middle Aged, Retinal Diseases/etiology, T-Lymphocytes/immunology, Transplantation, Homologous/adverse effects",
author = "Nora Mirza and Manfred Zierhut and Andreas Korn and Antje Bornemann and Wichard Vogel and Barbara Schmid-Horch and Bethge, {Wolfgang A} and Stefan Stevanovi{\'c} and Salih, {Helmut R} and Lothar Kanz and Hans-Georg Rammensee and Haen, {Sebastian P}",
year = "2016",
month = nov,
day = "29",
doi = "10.1073/pnas.1609118113",
language = "English",
volume = "113",
pages = "13827--13832",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "48",

}

RIS

TY - JOUR

T1 - Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft-host interaction

AU - Mirza, Nora

AU - Zierhut, Manfred

AU - Korn, Andreas

AU - Bornemann, Antje

AU - Vogel, Wichard

AU - Schmid-Horch, Barbara

AU - Bethge, Wolfgang A

AU - Stevanović, Stefan

AU - Salih, Helmut R

AU - Kanz, Lothar

AU - Rammensee, Hans-Georg

AU - Haen, Sebastian P

PY - 2016/11/29

Y1 - 2016/11/29

N2 - Graft-versus-host disease (GVHD) represents the major nonrelapse complication of allogeneic hematopoietic cell transplantation. Although rare, the CNS and the eye can be affected. In this study, manifestation in the retina as part of the CNS and T-cell epitopes recognized by the allogeneic T cells were evaluated. In 2 of 6 patients with posttransplantation retina diseases and 6 of 22 patients without ocular symptoms, antigen-specific T-cell responses against retina-specific epitopes were observed. No genetic differences between donor and recipient could be identified indicating T-cell activation against self-antigens (graft versus self). Transplantation of a preexisting immunity and cross-reactivity with ubiquitous epitopes was excluded in family donors and healthy individuals. In summary, an immunological reaction against retina cells represents a mechanism of graft-versus-host interaction following hematopoietic cell transplantation.

AB - Graft-versus-host disease (GVHD) represents the major nonrelapse complication of allogeneic hematopoietic cell transplantation. Although rare, the CNS and the eye can be affected. In this study, manifestation in the retina as part of the CNS and T-cell epitopes recognized by the allogeneic T cells were evaluated. In 2 of 6 patients with posttransplantation retina diseases and 6 of 22 patients without ocular symptoms, antigen-specific T-cell responses against retina-specific epitopes were observed. No genetic differences between donor and recipient could be identified indicating T-cell activation against self-antigens (graft versus self). Transplantation of a preexisting immunity and cross-reactivity with ubiquitous epitopes was excluded in family donors and healthy individuals. In summary, an immunological reaction against retina cells represents a mechanism of graft-versus-host interaction following hematopoietic cell transplantation.

KW - Adult

KW - Aged

KW - Autoantigens/immunology

KW - Epitopes, T-Lymphocyte/immunology

KW - Female

KW - Graft vs Host Disease/etiology

KW - Hematopoietic Stem Cell Transplantation/adverse effects

KW - Humans

KW - Lymphocyte Activation/immunology

KW - Male

KW - Middle Aged

KW - Retinal Diseases/etiology

KW - T-Lymphocytes/immunology

KW - Transplantation, Homologous/adverse effects

U2 - 10.1073/pnas.1609118113

DO - 10.1073/pnas.1609118113

M3 - SCORING: Journal article

C2 - 27834728

VL - 113

SP - 13827

EP - 13832

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 48

ER -