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Glucocorticoid receptors α and β are modulated sex specifically in human placentas of intrauterine growth restriction (IUGR)

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Glucocorticoid receptors α and β are modulated sex specifically in human placentas of intrauterine growth restriction (IUGR). / Hutter, Stefan; Hepp, Paula; Hofmann, Simone; Kuhn, Christina; Messner, Julia; Andergassen, Ulrich; Mayr, Doris; Emilia Solano, Maria; Obermeier, Viola; Mahner, Sven; Arck, Petra; Jeschke, Udo.

In: ARCH GYNECOL OBSTET, Vol. 300, No. 2, 08.2019, p. 323-335.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hutter, S, Hepp, P, Hofmann, S, Kuhn, C, Messner, J, Andergassen, U, Mayr, D, Emilia Solano, M, Obermeier, V, Mahner, S, Arck, P & Jeschke, U 2019, 'Glucocorticoid receptors α and β are modulated sex specifically in human placentas of intrauterine growth restriction (IUGR)', ARCH GYNECOL OBSTET, vol. 300, no. 2, pp. 323-335. https://doi.org/10.1007/s00404-019-05189-7

APA

Hutter, S., Hepp, P., Hofmann, S., Kuhn, C., Messner, J., Andergassen, U., Mayr, D., Emilia Solano, M., Obermeier, V., Mahner, S., Arck, P., & Jeschke, U. (2019). Glucocorticoid receptors α and β are modulated sex specifically in human placentas of intrauterine growth restriction (IUGR). ARCH GYNECOL OBSTET, 300(2), 323-335. https://doi.org/10.1007/s00404-019-05189-7

Vancouver

Hutter S, Hepp P, Hofmann S, Kuhn C, Messner J, Andergassen U et al. Glucocorticoid receptors α and β are modulated sex specifically in human placentas of intrauterine growth restriction (IUGR). ARCH GYNECOL OBSTET. 2019 Aug;300(2):323-335. https://doi.org/10.1007/s00404-019-05189-7

Bibtex

@article{435eeb0345a54056b44a48a44f178d05,
title = "Glucocorticoid receptors α and β are modulated sex specifically in human placentas of intrauterine growth restriction (IUGR)",
abstract = "PURPOSE: The objective of this study was to analyze the expression of the glucocorticoid receptor (GR) subtypes GRα and GRβ in placentas affected by intrauterine growth restriction (IUGR).METHODS: We analyzed the sex-specific placental expression of GRα and GRβ in 23 IUGR and 40 control placentas using immunohistochemistry and immunofluorescence. The GR gene, also known as nuclear receptor subfamily 3 group C member 1 (NR3C1), mRNA production in trophoblast-like cell line BeWo after stimulation with prednisolone was analyzed using quantitative polymerase chain reaction (qPCR) and on the protein level using western blot analysis.RESULTS: GR subtypes showed a sex-specific upregulation in placentas from IUGR compared to control placentas. An increased expression of GRα was detectable in female placental tissue, whereas GRβ was increased in males.CONCLUSION: Our data support previous findings suggesting that the glucocorticoid metabolism plays a role in the pathophysiology of IUGR. Furthermore, the data suggest that the underlying molecular mechanisms differ between male and female cases.",
keywords = "Journal Article",
author = "Stefan Hutter and Paula Hepp and Simone Hofmann and Christina Kuhn and Julia Messner and Ulrich Andergassen and Doris Mayr and {Emilia Solano}, Maria and Viola Obermeier and Sven Mahner and Petra Arck and Udo Jeschke",
year = "2019",
month = aug,
doi = "10.1007/s00404-019-05189-7",
language = "English",
volume = "300",
pages = "323--335",
journal = "ARCH GYNECOL OBSTET",
issn = "0932-0067",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Glucocorticoid receptors α and β are modulated sex specifically in human placentas of intrauterine growth restriction (IUGR)

AU - Hutter, Stefan

AU - Hepp, Paula

AU - Hofmann, Simone

AU - Kuhn, Christina

AU - Messner, Julia

AU - Andergassen, Ulrich

AU - Mayr, Doris

AU - Emilia Solano, Maria

AU - Obermeier, Viola

AU - Mahner, Sven

AU - Arck, Petra

AU - Jeschke, Udo

PY - 2019/8

Y1 - 2019/8

N2 - PURPOSE: The objective of this study was to analyze the expression of the glucocorticoid receptor (GR) subtypes GRα and GRβ in placentas affected by intrauterine growth restriction (IUGR).METHODS: We analyzed the sex-specific placental expression of GRα and GRβ in 23 IUGR and 40 control placentas using immunohistochemistry and immunofluorescence. The GR gene, also known as nuclear receptor subfamily 3 group C member 1 (NR3C1), mRNA production in trophoblast-like cell line BeWo after stimulation with prednisolone was analyzed using quantitative polymerase chain reaction (qPCR) and on the protein level using western blot analysis.RESULTS: GR subtypes showed a sex-specific upregulation in placentas from IUGR compared to control placentas. An increased expression of GRα was detectable in female placental tissue, whereas GRβ was increased in males.CONCLUSION: Our data support previous findings suggesting that the glucocorticoid metabolism plays a role in the pathophysiology of IUGR. Furthermore, the data suggest that the underlying molecular mechanisms differ between male and female cases.

AB - PURPOSE: The objective of this study was to analyze the expression of the glucocorticoid receptor (GR) subtypes GRα and GRβ in placentas affected by intrauterine growth restriction (IUGR).METHODS: We analyzed the sex-specific placental expression of GRα and GRβ in 23 IUGR and 40 control placentas using immunohistochemistry and immunofluorescence. The GR gene, also known as nuclear receptor subfamily 3 group C member 1 (NR3C1), mRNA production in trophoblast-like cell line BeWo after stimulation with prednisolone was analyzed using quantitative polymerase chain reaction (qPCR) and on the protein level using western blot analysis.RESULTS: GR subtypes showed a sex-specific upregulation in placentas from IUGR compared to control placentas. An increased expression of GRα was detectable in female placental tissue, whereas GRβ was increased in males.CONCLUSION: Our data support previous findings suggesting that the glucocorticoid metabolism plays a role in the pathophysiology of IUGR. Furthermore, the data suggest that the underlying molecular mechanisms differ between male and female cases.

KW - Journal Article

U2 - 10.1007/s00404-019-05189-7

DO - 10.1007/s00404-019-05189-7

M3 - SCORING: Journal article

C2 - 31089804

VL - 300

SP - 323

EP - 335

JO - ARCH GYNECOL OBSTET

JF - ARCH GYNECOL OBSTET

SN - 0932-0067

IS - 2

ER -