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Glioblastoma stem-like cell lines with either maintenance or loss of high-level EGFR amplification, generated via modulation of ligand concentration.

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Glioblastoma stem-like cell lines with either maintenance or loss of high-level EGFR amplification, generated via modulation of ligand concentration. / Schulte, Alexander; Günther, Hauke; Martens, Tobias; Zapf, Svenja; Riethdorf, Sabine; Wülfing, Clemens; Stoupiec, Malgorzata; Westphal, Manfred; Lamszus, Katrin.

In: CLIN CANCER RES, Vol. 18, No. 7, 7, 2012, p. 1901-1913.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schulte, A, Günther, H, Martens, T, Zapf, S, Riethdorf, S, Wülfing, C, Stoupiec, M, Westphal, M & Lamszus, K 2012, 'Glioblastoma stem-like cell lines with either maintenance or loss of high-level EGFR amplification, generated via modulation of ligand concentration.', CLIN CANCER RES, vol. 18, no. 7, 7, pp. 1901-1913. <http://www.ncbi.nlm.nih.gov/pubmed/22316604?dopt=Citation>

APA

Schulte, A., Günther, H., Martens, T., Zapf, S., Riethdorf, S., Wülfing, C., Stoupiec, M., Westphal, M., & Lamszus, K. (2012). Glioblastoma stem-like cell lines with either maintenance or loss of high-level EGFR amplification, generated via modulation of ligand concentration. CLIN CANCER RES, 18(7), 1901-1913. [7]. http://www.ncbi.nlm.nih.gov/pubmed/22316604?dopt=Citation

Vancouver

Schulte A, Günther H, Martens T, Zapf S, Riethdorf S, Wülfing C et al. Glioblastoma stem-like cell lines with either maintenance or loss of high-level EGFR amplification, generated via modulation of ligand concentration. CLIN CANCER RES. 2012;18(7):1901-1913. 7.

Bibtex

@article{36fb5dc4426a443297653871f15ac1f7,
title = "Glioblastoma stem-like cell lines with either maintenance or loss of high-level EGFR amplification, generated via modulation of ligand concentration.",
abstract = "Despite the high incidence of epidermal growth factor receptor (EGFR) gene amplification and rearrangement in glioblastomas, no suitable cell line exists that preserves these alterations in vitro and is tumorigenic in immunocompromised mice. On the basis of previous observations that glioblastoma cells cultured with serum lose the EGFR amplification rapidly and that EGF can inhibit the growth of EGFR-amplified tumor cells, we hypothesized that serum-free and EGF-free culture conditions could promote maintenance of the EGFR amplification.",
author = "Alexander Schulte and Hauke G{\"u}nther and Tobias Martens and Svenja Zapf and Sabine Riethdorf and Clemens W{\"u}lfing and Malgorzata Stoupiec and Manfred Westphal and Katrin Lamszus",
year = "2012",
language = "English",
volume = "18",
pages = "1901--1913",
journal = "CLIN CANCER RES",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - Glioblastoma stem-like cell lines with either maintenance or loss of high-level EGFR amplification, generated via modulation of ligand concentration.

AU - Schulte, Alexander

AU - Günther, Hauke

AU - Martens, Tobias

AU - Zapf, Svenja

AU - Riethdorf, Sabine

AU - Wülfing, Clemens

AU - Stoupiec, Malgorzata

AU - Westphal, Manfred

AU - Lamszus, Katrin

PY - 2012

Y1 - 2012

N2 - Despite the high incidence of epidermal growth factor receptor (EGFR) gene amplification and rearrangement in glioblastomas, no suitable cell line exists that preserves these alterations in vitro and is tumorigenic in immunocompromised mice. On the basis of previous observations that glioblastoma cells cultured with serum lose the EGFR amplification rapidly and that EGF can inhibit the growth of EGFR-amplified tumor cells, we hypothesized that serum-free and EGF-free culture conditions could promote maintenance of the EGFR amplification.

AB - Despite the high incidence of epidermal growth factor receptor (EGFR) gene amplification and rearrangement in glioblastomas, no suitable cell line exists that preserves these alterations in vitro and is tumorigenic in immunocompromised mice. On the basis of previous observations that glioblastoma cells cultured with serum lose the EGFR amplification rapidly and that EGF can inhibit the growth of EGFR-amplified tumor cells, we hypothesized that serum-free and EGF-free culture conditions could promote maintenance of the EGFR amplification.

M3 - SCORING: Journal article

VL - 18

SP - 1901

EP - 1913

JO - CLIN CANCER RES

JF - CLIN CANCER RES

SN - 1078-0432

IS - 7

M1 - 7

ER -