Genomic analysis in nephrology--towards systems biology and systematic medicine?
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Genomic analysis in nephrology--towards systems biology and systematic medicine? / Neusser, Matthias A; Lindenmeyer, Maja T; Kretzler, Matthias; Cohen, Clemens D.
In: NEPHROL THER, Vol. 4, No. 5, 10.2008, p. 306-11.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Genomic analysis in nephrology--towards systems biology and systematic medicine?
AU - Neusser, Matthias A
AU - Lindenmeyer, Maja T
AU - Kretzler, Matthias
AU - Cohen, Clemens D
PY - 2008/10
Y1 - 2008/10
N2 - With the advent of transcriptome profiling techniques, an enormous amount of data has been generated in the field of molecular nephrology. We will review analysis tools and challenges for genomic approaches and present their application in gene-expression studies on kidney biopsies. The findings in this rapidly evolving field may ultimately complement histopathological analysis, the current diagnostic and prognostic gold standard. Altogether, genomics may bring nephrology one-step closer to a systematic understanding of biological processes involved in renal disease.
AB - With the advent of transcriptome profiling techniques, an enormous amount of data has been generated in the field of molecular nephrology. We will review analysis tools and challenges for genomic approaches and present their application in gene-expression studies on kidney biopsies. The findings in this rapidly evolving field may ultimately complement histopathological analysis, the current diagnostic and prognostic gold standard. Altogether, genomics may bring nephrology one-step closer to a systematic understanding of biological processes involved in renal disease.
KW - Biopsy
KW - Computational Biology
KW - Gene Expression
KW - Gene Expression Profiling
KW - Genomics
KW - Humans
KW - Kidney
KW - Kidney Diseases
KW - Kidney Transplantation
KW - Nephrology
KW - RNA, Messenger
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Treatment Failure
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Review
U2 - 10.1016/j.nephro.2008.04.003
DO - 10.1016/j.nephro.2008.04.003
M3 - SCORING: Review article
C2 - 18586598
VL - 4
SP - 306
EP - 311
JO - NEPHROL THER
JF - NEPHROL THER
SN - 1769-7255
IS - 5
ER -