Genomic analysis in nephrology--towards systems biology and systematic medicine?

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Genomic analysis in nephrology--towards systems biology and systematic medicine? / Neusser, Matthias A; Lindenmeyer, Maja T; Kretzler, Matthias; Cohen, Clemens D.

in: NEPHROL THER, Jahrgang 4, Nr. 5, 10.2008, S. 306-11.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ReviewForschung

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@article{9008464238754132b1be2954b7ac4ffa,
title = "Genomic analysis in nephrology--towards systems biology and systematic medicine?",
abstract = "With the advent of transcriptome profiling techniques, an enormous amount of data has been generated in the field of molecular nephrology. We will review analysis tools and challenges for genomic approaches and present their application in gene-expression studies on kidney biopsies. The findings in this rapidly evolving field may ultimately complement histopathological analysis, the current diagnostic and prognostic gold standard. Altogether, genomics may bring nephrology one-step closer to a systematic understanding of biological processes involved in renal disease.",
keywords = "Biopsy, Computational Biology, Gene Expression, Gene Expression Profiling, Genomics, Humans, Kidney, Kidney Diseases, Kidney Transplantation, Nephrology, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction, Treatment Failure, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Neusser, {Matthias A} and Lindenmeyer, {Maja T} and Matthias Kretzler and Cohen, {Clemens D}",
year = "2008",
month = oct,
doi = "10.1016/j.nephro.2008.04.003",
language = "English",
volume = "4",
pages = "306--11",
journal = "NEPHROL THER",
issn = "1769-7255",
publisher = "Elsevier Masson",
number = "5",

}

RIS

TY - JOUR

T1 - Genomic analysis in nephrology--towards systems biology and systematic medicine?

AU - Neusser, Matthias A

AU - Lindenmeyer, Maja T

AU - Kretzler, Matthias

AU - Cohen, Clemens D

PY - 2008/10

Y1 - 2008/10

N2 - With the advent of transcriptome profiling techniques, an enormous amount of data has been generated in the field of molecular nephrology. We will review analysis tools and challenges for genomic approaches and present their application in gene-expression studies on kidney biopsies. The findings in this rapidly evolving field may ultimately complement histopathological analysis, the current diagnostic and prognostic gold standard. Altogether, genomics may bring nephrology one-step closer to a systematic understanding of biological processes involved in renal disease.

AB - With the advent of transcriptome profiling techniques, an enormous amount of data has been generated in the field of molecular nephrology. We will review analysis tools and challenges for genomic approaches and present their application in gene-expression studies on kidney biopsies. The findings in this rapidly evolving field may ultimately complement histopathological analysis, the current diagnostic and prognostic gold standard. Altogether, genomics may bring nephrology one-step closer to a systematic understanding of biological processes involved in renal disease.

KW - Biopsy

KW - Computational Biology

KW - Gene Expression

KW - Gene Expression Profiling

KW - Genomics

KW - Humans

KW - Kidney

KW - Kidney Diseases

KW - Kidney Transplantation

KW - Nephrology

KW - RNA, Messenger

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Treatment Failure

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1016/j.nephro.2008.04.003

DO - 10.1016/j.nephro.2008.04.003

M3 - SCORING: Review article

C2 - 18586598

VL - 4

SP - 306

EP - 311

JO - NEPHROL THER

JF - NEPHROL THER

SN - 1769-7255

IS - 5

ER -