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Genomewide association studies in cardiovascular disease--an update 2011

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Genomewide association studies in cardiovascular disease--an update 2011. / Zeller, Tanja; Blankenberg, Stefan; Diemert, Patrick.

In: CLIN CHEM, Vol. 58, No. 1, 01.2012, p. 92-103.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Zeller, T, Blankenberg, S & Diemert, P 2012, 'Genomewide association studies in cardiovascular disease--an update 2011', CLIN CHEM, vol. 58, no. 1, pp. 92-103. https://doi.org/10.1373/clinchem.2011.170431

APA

Zeller, T., Blankenberg, S., & Diemert, P. (2012). Genomewide association studies in cardiovascular disease--an update 2011. CLIN CHEM, 58(1), 92-103. https://doi.org/10.1373/clinchem.2011.170431

Vancouver

Zeller T, Blankenberg S, Diemert P. Genomewide association studies in cardiovascular disease--an update 2011. CLIN CHEM. 2012 Jan;58(1):92-103. https://doi.org/10.1373/clinchem.2011.170431

Bibtex

@article{6f55ee65e635419ebdd86040da7651d2,
title = "Genomewide association studies in cardiovascular disease--an update 2011",
abstract = "BACKGROUND: Genomewide association studies have led to an enormous boost in the identification of susceptibility genes for cardiovascular diseases. This review aims to summarize the most important findings of recent years.CONTENT: We have carefully reviewed the current literature (PubMed search terms: {"}genome wide association studies,{"} {"}genetic polymorphism,{"} {"}genetic risk factors,{"} {"}association study{"} in connection with the respective diseases, {"}risk score,{"} {"}transcriptome{"}).SUMMARY: Multiple novel genetic loci for such important cardiovascular diseases as myocardial infarction, hypertension, heart failure, stroke, and hyperlipidemia have been identified. Given that many novel genetic risk factors lie within hitherto-unsuspected genes or influence gene expression, these findings have inspired discoveries of biological function. Despite these successes, however, only a fraction of the heritability for most cardiovascular diseases has been explained thus far. Forthcoming techniques such as whole-genome sequencing will be important to close the gap of missing heritability.",
keywords = "Adaptor Proteins, Vesicular Transport/genetics, Animals, Cardiovascular Diseases/drug therapy, Chromosomes, Human, Pair 1/genetics, Genetic Loci, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study/methods, Humans, Pharmacogenetics, Polymorphism, Single Nucleotide, Risk Assessment, Transcriptome/genetics",
author = "Tanja Zeller and Stefan Blankenberg and Patrick Diemert",
year = "2012",
month = jan,
doi = "10.1373/clinchem.2011.170431",
language = "English",
volume = "58",
pages = "92--103",
journal = "CLIN CHEM",
issn = "0009-9147",
publisher = "American Association for Clinical Chemistry Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Genomewide association studies in cardiovascular disease--an update 2011

AU - Zeller, Tanja

AU - Blankenberg, Stefan

AU - Diemert, Patrick

PY - 2012/1

Y1 - 2012/1

N2 - BACKGROUND: Genomewide association studies have led to an enormous boost in the identification of susceptibility genes for cardiovascular diseases. This review aims to summarize the most important findings of recent years.CONTENT: We have carefully reviewed the current literature (PubMed search terms: "genome wide association studies," "genetic polymorphism," "genetic risk factors," "association study" in connection with the respective diseases, "risk score," "transcriptome").SUMMARY: Multiple novel genetic loci for such important cardiovascular diseases as myocardial infarction, hypertension, heart failure, stroke, and hyperlipidemia have been identified. Given that many novel genetic risk factors lie within hitherto-unsuspected genes or influence gene expression, these findings have inspired discoveries of biological function. Despite these successes, however, only a fraction of the heritability for most cardiovascular diseases has been explained thus far. Forthcoming techniques such as whole-genome sequencing will be important to close the gap of missing heritability.

AB - BACKGROUND: Genomewide association studies have led to an enormous boost in the identification of susceptibility genes for cardiovascular diseases. This review aims to summarize the most important findings of recent years.CONTENT: We have carefully reviewed the current literature (PubMed search terms: "genome wide association studies," "genetic polymorphism," "genetic risk factors," "association study" in connection with the respective diseases, "risk score," "transcriptome").SUMMARY: Multiple novel genetic loci for such important cardiovascular diseases as myocardial infarction, hypertension, heart failure, stroke, and hyperlipidemia have been identified. Given that many novel genetic risk factors lie within hitherto-unsuspected genes or influence gene expression, these findings have inspired discoveries of biological function. Despite these successes, however, only a fraction of the heritability for most cardiovascular diseases has been explained thus far. Forthcoming techniques such as whole-genome sequencing will be important to close the gap of missing heritability.

KW - Adaptor Proteins, Vesicular Transport/genetics

KW - Animals

KW - Cardiovascular Diseases/drug therapy

KW - Chromosomes, Human, Pair 1/genetics

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome, Human

KW - Genome-Wide Association Study/methods

KW - Humans

KW - Pharmacogenetics

KW - Polymorphism, Single Nucleotide

KW - Risk Assessment

KW - Transcriptome/genetics

U2 - 10.1373/clinchem.2011.170431

DO - 10.1373/clinchem.2011.170431

M3 - SCORING: Review article

C2 - 22125304

VL - 58

SP - 92

EP - 103

JO - CLIN CHEM

JF - CLIN CHEM

SN - 0009-9147

IS - 1

ER -