Genomewide association studies in cardiovascular disease--an update 2011
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Genomewide association studies in cardiovascular disease--an update 2011. / Zeller, Tanja; Blankenberg, Stefan; Diemert, Patrick.
in: CLIN CHEM, Jahrgang 58, Nr. 1, 01.2012, S. 92-103.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Genomewide association studies in cardiovascular disease--an update 2011
AU - Zeller, Tanja
AU - Blankenberg, Stefan
AU - Diemert, Patrick
PY - 2012/1
Y1 - 2012/1
N2 - BACKGROUND: Genomewide association studies have led to an enormous boost in the identification of susceptibility genes for cardiovascular diseases. This review aims to summarize the most important findings of recent years.CONTENT: We have carefully reviewed the current literature (PubMed search terms: "genome wide association studies," "genetic polymorphism," "genetic risk factors," "association study" in connection with the respective diseases, "risk score," "transcriptome").SUMMARY: Multiple novel genetic loci for such important cardiovascular diseases as myocardial infarction, hypertension, heart failure, stroke, and hyperlipidemia have been identified. Given that many novel genetic risk factors lie within hitherto-unsuspected genes or influence gene expression, these findings have inspired discoveries of biological function. Despite these successes, however, only a fraction of the heritability for most cardiovascular diseases has been explained thus far. Forthcoming techniques such as whole-genome sequencing will be important to close the gap of missing heritability.
AB - BACKGROUND: Genomewide association studies have led to an enormous boost in the identification of susceptibility genes for cardiovascular diseases. This review aims to summarize the most important findings of recent years.CONTENT: We have carefully reviewed the current literature (PubMed search terms: "genome wide association studies," "genetic polymorphism," "genetic risk factors," "association study" in connection with the respective diseases, "risk score," "transcriptome").SUMMARY: Multiple novel genetic loci for such important cardiovascular diseases as myocardial infarction, hypertension, heart failure, stroke, and hyperlipidemia have been identified. Given that many novel genetic risk factors lie within hitherto-unsuspected genes or influence gene expression, these findings have inspired discoveries of biological function. Despite these successes, however, only a fraction of the heritability for most cardiovascular diseases has been explained thus far. Forthcoming techniques such as whole-genome sequencing will be important to close the gap of missing heritability.
KW - Adaptor Proteins, Vesicular Transport/genetics
KW - Animals
KW - Cardiovascular Diseases/drug therapy
KW - Chromosomes, Human, Pair 1/genetics
KW - Genetic Loci
KW - Genetic Predisposition to Disease
KW - Genome, Human
KW - Genome-Wide Association Study/methods
KW - Humans
KW - Pharmacogenetics
KW - Polymorphism, Single Nucleotide
KW - Risk Assessment
KW - Transcriptome/genetics
U2 - 10.1373/clinchem.2011.170431
DO - 10.1373/clinchem.2011.170431
M3 - SCORING: Review article
C2 - 22125304
VL - 58
SP - 92
EP - 103
JO - CLIN CHEM
JF - CLIN CHEM
SN - 0009-9147
IS - 1
ER -