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Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations

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Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations. / Karakas, Mahir; Hoffmann, Michael M; Vollmert, Caren; Rothenbacher, Dietrich; Meisinger, Christa; Winkelmann, Bernhard; Khuseyinova, Natalie; Böhm, Bernhard O; Illig, Thomas; März, Winfried; Koenig, Wolfgang.

In: BMC MED GENET, Vol. 10, 46, 29.05.2009.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

Karakas, M, Hoffmann, MM, Vollmert, C, Rothenbacher, D, Meisinger, C, Winkelmann, B, Khuseyinova, N, Böhm, BO, Illig, T, März, W & Koenig, W 2009, 'Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations', BMC MED GENET, vol. 10, 46. https://doi.org/10.1186/1471-2350-10-46

APA

Karakas, M., Hoffmann, M. M., Vollmert, C., Rothenbacher, D., Meisinger, C., Winkelmann, B., Khuseyinova, N., Böhm, B. O., Illig, T., März, W., & Koenig, W. (2009). Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations. BMC MED GENET, 10, [46]. https://doi.org/10.1186/1471-2350-10-46

Vancouver

Karakas M, Hoffmann MM, Vollmert C, Rothenbacher D, Meisinger C, Winkelmann B et al. Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations. BMC MED GENET. 2009 May 29;10. 46. https://doi.org/10.1186/1471-2350-10-46

Bibtex

@article{65874877eedf42bb8850b9c0b7bcc5a7,
title = "Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations",
abstract = "BACKGROUND: The role of the Fc gamma receptor IIa (Fc gamma RIIa), a receptor for C-reactive protein (CRP), the classical acute phase protein, in atherosclerosis is not yet clear. We sought to investigate the association of Fc gamma RIIa genotype with risk of coronary heart disease (CHD) in two large population-based samples.METHODS: Fc gamma RIIa-R/H131 polymorphisms were determined in a population of 527 patients with a history of myocardial infarction and 527 age and gender matched controls drawn from a population-based MONICA- Augsburg survey. In the LURIC population, 2227 patients with angiographically proven CHD, defined as having at least one stenosis >or= 50%, were compared with 1032 individuals with stenosis <50%.RESULTS: In both populations genotype frequencies of the Fc gamma RIIa gene did not show a significant departure from the Hardy-Weinberg equilibrium. Fc gamma RIIa R(-131) --> H genotype was not independently associated with lower risk of CHD after multivariable adjustments, neither in the MONICA population (odds ratio (OR) 1.08; 95% confidence interval (CI) 0.81 to 1.44), nor in LURIC (OR 0.96; 95% CI 0.81 to 1.14).CONCLUSION: Our results do not confirm an independent relationship between Fc gamma RIIa genotypes and risk of CHD in these populations.",
keywords = "Aged, Alleles, Case-Control Studies, Coronary Disease/genetics, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Male, Middle Aged, Odds Ratio, Polymorphism, Genetic, Receptors, IgG/genetics, Risk Factors",
author = "Mahir Karakas and Hoffmann, {Michael M} and Caren Vollmert and Dietrich Rothenbacher and Christa Meisinger and Bernhard Winkelmann and Natalie Khuseyinova and B{\"o}hm, {Bernhard O} and Thomas Illig and Winfried M{\"a}rz and Wolfgang Koenig",
year = "2009",
month = may,
day = "29",
doi = "10.1186/1471-2350-10-46",
language = "English",
volume = "10",
journal = "BMC MED GENET",
issn = "1471-2350",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations

AU - Karakas, Mahir

AU - Hoffmann, Michael M

AU - Vollmert, Caren

AU - Rothenbacher, Dietrich

AU - Meisinger, Christa

AU - Winkelmann, Bernhard

AU - Khuseyinova, Natalie

AU - Böhm, Bernhard O

AU - Illig, Thomas

AU - März, Winfried

AU - Koenig, Wolfgang

PY - 2009/5/29

Y1 - 2009/5/29

N2 - BACKGROUND: The role of the Fc gamma receptor IIa (Fc gamma RIIa), a receptor for C-reactive protein (CRP), the classical acute phase protein, in atherosclerosis is not yet clear. We sought to investigate the association of Fc gamma RIIa genotype with risk of coronary heart disease (CHD) in two large population-based samples.METHODS: Fc gamma RIIa-R/H131 polymorphisms were determined in a population of 527 patients with a history of myocardial infarction and 527 age and gender matched controls drawn from a population-based MONICA- Augsburg survey. In the LURIC population, 2227 patients with angiographically proven CHD, defined as having at least one stenosis >or= 50%, were compared with 1032 individuals with stenosis <50%.RESULTS: In both populations genotype frequencies of the Fc gamma RIIa gene did not show a significant departure from the Hardy-Weinberg equilibrium. Fc gamma RIIa R(-131) --> H genotype was not independently associated with lower risk of CHD after multivariable adjustments, neither in the MONICA population (odds ratio (OR) 1.08; 95% confidence interval (CI) 0.81 to 1.44), nor in LURIC (OR 0.96; 95% CI 0.81 to 1.14).CONCLUSION: Our results do not confirm an independent relationship between Fc gamma RIIa genotypes and risk of CHD in these populations.

AB - BACKGROUND: The role of the Fc gamma receptor IIa (Fc gamma RIIa), a receptor for C-reactive protein (CRP), the classical acute phase protein, in atherosclerosis is not yet clear. We sought to investigate the association of Fc gamma RIIa genotype with risk of coronary heart disease (CHD) in two large population-based samples.METHODS: Fc gamma RIIa-R/H131 polymorphisms were determined in a population of 527 patients with a history of myocardial infarction and 527 age and gender matched controls drawn from a population-based MONICA- Augsburg survey. In the LURIC population, 2227 patients with angiographically proven CHD, defined as having at least one stenosis >or= 50%, were compared with 1032 individuals with stenosis <50%.RESULTS: In both populations genotype frequencies of the Fc gamma RIIa gene did not show a significant departure from the Hardy-Weinberg equilibrium. Fc gamma RIIa R(-131) --> H genotype was not independently associated with lower risk of CHD after multivariable adjustments, neither in the MONICA population (odds ratio (OR) 1.08; 95% confidence interval (CI) 0.81 to 1.44), nor in LURIC (OR 0.96; 95% CI 0.81 to 1.14).CONCLUSION: Our results do not confirm an independent relationship between Fc gamma RIIa genotypes and risk of CHD in these populations.

KW - Aged

KW - Alleles

KW - Case-Control Studies

KW - Coronary Disease/genetics

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Genetic Variation

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Polymorphism, Genetic

KW - Receptors, IgG/genetics

KW - Risk Factors

U2 - 10.1186/1471-2350-10-46

DO - 10.1186/1471-2350-10-46

M3 - SCORING: Journal article

C2 - 19480687

VL - 10

JO - BMC MED GENET

JF - BMC MED GENET

SN - 1471-2350

M1 - 46

ER -