Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations
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Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations. / Karakas, Mahir; Hoffmann, Michael M; Vollmert, Caren; Rothenbacher, Dietrich; Meisinger, Christa; Winkelmann, Bernhard; Khuseyinova, Natalie; Böhm, Bernhard O; Illig, Thomas; März, Winfried; Koenig, Wolfgang.
in: BMC MED GENET, Jahrgang 10, 46, 29.05.2009.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung
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T1 - Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations
AU - Karakas, Mahir
AU - Hoffmann, Michael M
AU - Vollmert, Caren
AU - Rothenbacher, Dietrich
AU - Meisinger, Christa
AU - Winkelmann, Bernhard
AU - Khuseyinova, Natalie
AU - Böhm, Bernhard O
AU - Illig, Thomas
AU - März, Winfried
AU - Koenig, Wolfgang
PY - 2009/5/29
Y1 - 2009/5/29
N2 - BACKGROUND: The role of the Fc gamma receptor IIa (Fc gamma RIIa), a receptor for C-reactive protein (CRP), the classical acute phase protein, in atherosclerosis is not yet clear. We sought to investigate the association of Fc gamma RIIa genotype with risk of coronary heart disease (CHD) in two large population-based samples.METHODS: Fc gamma RIIa-R/H131 polymorphisms were determined in a population of 527 patients with a history of myocardial infarction and 527 age and gender matched controls drawn from a population-based MONICA- Augsburg survey. In the LURIC population, 2227 patients with angiographically proven CHD, defined as having at least one stenosis >or= 50%, were compared with 1032 individuals with stenosis <50%.RESULTS: In both populations genotype frequencies of the Fc gamma RIIa gene did not show a significant departure from the Hardy-Weinberg equilibrium. Fc gamma RIIa R(-131) --> H genotype was not independently associated with lower risk of CHD after multivariable adjustments, neither in the MONICA population (odds ratio (OR) 1.08; 95% confidence interval (CI) 0.81 to 1.44), nor in LURIC (OR 0.96; 95% CI 0.81 to 1.14).CONCLUSION: Our results do not confirm an independent relationship between Fc gamma RIIa genotypes and risk of CHD in these populations.
AB - BACKGROUND: The role of the Fc gamma receptor IIa (Fc gamma RIIa), a receptor for C-reactive protein (CRP), the classical acute phase protein, in atherosclerosis is not yet clear. We sought to investigate the association of Fc gamma RIIa genotype with risk of coronary heart disease (CHD) in two large population-based samples.METHODS: Fc gamma RIIa-R/H131 polymorphisms were determined in a population of 527 patients with a history of myocardial infarction and 527 age and gender matched controls drawn from a population-based MONICA- Augsburg survey. In the LURIC population, 2227 patients with angiographically proven CHD, defined as having at least one stenosis >or= 50%, were compared with 1032 individuals with stenosis <50%.RESULTS: In both populations genotype frequencies of the Fc gamma RIIa gene did not show a significant departure from the Hardy-Weinberg equilibrium. Fc gamma RIIa R(-131) --> H genotype was not independently associated with lower risk of CHD after multivariable adjustments, neither in the MONICA population (odds ratio (OR) 1.08; 95% confidence interval (CI) 0.81 to 1.44), nor in LURIC (OR 0.96; 95% CI 0.81 to 1.14).CONCLUSION: Our results do not confirm an independent relationship between Fc gamma RIIa genotypes and risk of CHD in these populations.
KW - Aged
KW - Alleles
KW - Case-Control Studies
KW - Coronary Disease/genetics
KW - Female
KW - Gene Frequency
KW - Genetic Predisposition to Disease
KW - Genetic Variation
KW - Genotype
KW - Humans
KW - Male
KW - Middle Aged
KW - Odds Ratio
KW - Polymorphism, Genetic
KW - Receptors, IgG/genetics
KW - Risk Factors
U2 - 10.1186/1471-2350-10-46
DO - 10.1186/1471-2350-10-46
M3 - SCORING: Journal article
C2 - 19480687
VL - 10
JO - BMC MED GENET
JF - BMC MED GENET
SN - 1471-2350
M1 - 46
ER -