Genetic animal models for retinal degeneration

TY - JOUR

T1 - Genetic animal models for retinal degeneration

AU - Fauser, Sascha

AU - Luberichs, Janina

AU - Schüttauf, Frank

PY - 2002/8/6

Y1 - 2002/8/6

N2 - Inherited retinal degenerations are a common cause of blindness in Western countries. A mechanism for most retinal degenerations is still unknown; hence, a suitable treatment for most of these diseases has yet to be found. Before one can rationally design a treatment, it is necessary to understand the pathway from a gene mutation to the phenotype in patients. Animal models are crucial to understand this process and to develop a treatment. Some naturally occurring animal models are known. However, over the past few years, transgenic engineering has allowed the generation of a rapidly growing number of animal models. In this review, we give an overview of the broad variety of genetic animal models for retinal degeneration.

AB - Inherited retinal degenerations are a common cause of blindness in Western countries. A mechanism for most retinal degenerations is still unknown; hence, a suitable treatment for most of these diseases has yet to be found. Before one can rationally design a treatment, it is necessary to understand the pathway from a gene mutation to the phenotype in patients. Animal models are crucial to understand this process and to develop a treatment. Some naturally occurring animal models are known. However, over the past few years, transgenic engineering has allowed the generation of a rapidly growing number of animal models. In this review, we give an overview of the broad variety of genetic animal models for retinal degeneration.

KW - Animals

KW - Animals, Genetically Modified/genetics

KW - Models, Animal

KW - Mutation

KW - Retinal Degeneration/genetics

U2 - 10.1016/s0039-6257(02)00314-4

DO - 10.1016/s0039-6257(02)00314-4

M3 - SCORING: Review article

C2 - 12161211

VL - 47

SP - 357

EP - 367

JO - SURV OPHTHALMOL

JF - SURV OPHTHALMOL

SN - 0039-6257

IS - 4

ER -