Genetic animal models for retinal degeneration
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Genetic animal models for retinal degeneration. / Fauser, Sascha; Luberichs, Janina; Schüttauf, Frank.
in: SURV OPHTHALMOL, Jahrgang 47, Nr. 4, 06.08.2002, S. 357-67.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Genetic animal models for retinal degeneration
AU - Fauser, Sascha
AU - Luberichs, Janina
AU - Schüttauf, Frank
PY - 2002/8/6
Y1 - 2002/8/6
N2 - Inherited retinal degenerations are a common cause of blindness in Western countries. A mechanism for most retinal degenerations is still unknown; hence, a suitable treatment for most of these diseases has yet to be found. Before one can rationally design a treatment, it is necessary to understand the pathway from a gene mutation to the phenotype in patients. Animal models are crucial to understand this process and to develop a treatment. Some naturally occurring animal models are known. However, over the past few years, transgenic engineering has allowed the generation of a rapidly growing number of animal models. In this review, we give an overview of the broad variety of genetic animal models for retinal degeneration.
AB - Inherited retinal degenerations are a common cause of blindness in Western countries. A mechanism for most retinal degenerations is still unknown; hence, a suitable treatment for most of these diseases has yet to be found. Before one can rationally design a treatment, it is necessary to understand the pathway from a gene mutation to the phenotype in patients. Animal models are crucial to understand this process and to develop a treatment. Some naturally occurring animal models are known. However, over the past few years, transgenic engineering has allowed the generation of a rapidly growing number of animal models. In this review, we give an overview of the broad variety of genetic animal models for retinal degeneration.
KW - Animals
KW - Animals, Genetically Modified/genetics
KW - Models, Animal
KW - Mutation
KW - Retinal Degeneration/genetics
U2 - 10.1016/s0039-6257(02)00314-4
DO - 10.1016/s0039-6257(02)00314-4
M3 - SCORING: Review article
C2 - 12161211
VL - 47
SP - 357
EP - 367
JO - SURV OPHTHALMOL
JF - SURV OPHTHALMOL
SN - 0039-6257
IS - 4
ER -