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GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease

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GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease. / Kramer, Edgar R; Liss, Birgit.

In: FEBS LETT, Vol. 589, No. 24 Pt A, 21.12.2015, p. 3760-72.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kramer, ER & Liss, B 2015, 'GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease', FEBS LETT, vol. 589, no. 24 Pt A, pp. 3760-72. https://doi.org/10.1016/j.febslet.2015.11.006

APA

Kramer, E. R., & Liss, B. (2015). GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease. FEBS LETT, 589(24 Pt A), 3760-72. https://doi.org/10.1016/j.febslet.2015.11.006

Vancouver

Kramer ER, Liss B. GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease. FEBS LETT. 2015 Dec 21;589(24 Pt A):3760-72. https://doi.org/10.1016/j.febslet.2015.11.006

Bibtex

@article{36c5fc1037f847e79c35fe81a30b1d7e,
title = "GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease",
abstract = "Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriatal DA system, the physiological functions of GDNF for the DA system are still unclear. Nevertheless, GDNF is still considered to be an excellent candidate to protect and/or regenerate the mesostriatal DA system in Parkinson disease (PD). Clinical trials with GDNF on PD patients are, however, so far inconclusive. Here, we review the current knowledge of GDNF and Ret signaling and function in the midbrain DA system, and their crosstalk with proteins and signaling pathways associated with PD.",
author = "Kramer, {Edgar R} and Birgit Liss",
note = "Copyright {\textcopyright} 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",
year = "2015",
month = dec,
day = "21",
doi = "10.1016/j.febslet.2015.11.006",
language = "English",
volume = "589",
pages = "3760--72",
journal = "FEBS LETT",
issn = "0014-5793",
publisher = "Elsevier",
number = "24 Pt A",

}

RIS

TY - JOUR

T1 - GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease

AU - Kramer, Edgar R

AU - Liss, Birgit

N1 - Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

PY - 2015/12/21

Y1 - 2015/12/21

N2 - Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriatal DA system, the physiological functions of GDNF for the DA system are still unclear. Nevertheless, GDNF is still considered to be an excellent candidate to protect and/or regenerate the mesostriatal DA system in Parkinson disease (PD). Clinical trials with GDNF on PD patients are, however, so far inconclusive. Here, we review the current knowledge of GDNF and Ret signaling and function in the midbrain DA system, and their crosstalk with proteins and signaling pathways associated with PD.

AB - Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriatal DA system, the physiological functions of GDNF for the DA system are still unclear. Nevertheless, GDNF is still considered to be an excellent candidate to protect and/or regenerate the mesostriatal DA system in Parkinson disease (PD). Clinical trials with GDNF on PD patients are, however, so far inconclusive. Here, we review the current knowledge of GDNF and Ret signaling and function in the midbrain DA system, and their crosstalk with proteins and signaling pathways associated with PD.

U2 - 10.1016/j.febslet.2015.11.006

DO - 10.1016/j.febslet.2015.11.006

M3 - SCORING: Journal article

C2 - 26555190

VL - 589

SP - 3760

EP - 3772

JO - FEBS LETT

JF - FEBS LETT

SN - 0014-5793

IS - 24 Pt A

ER -