GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease
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GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease. / Kramer, Edgar R; Liss, Birgit.
in: FEBS LETT, Jahrgang 589, Nr. 24 Pt A, 21.12.2015, S. 3760-72.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease
AU - Kramer, Edgar R
AU - Liss, Birgit
N1 - Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
PY - 2015/12/21
Y1 - 2015/12/21
N2 - Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriatal DA system, the physiological functions of GDNF for the DA system are still unclear. Nevertheless, GDNF is still considered to be an excellent candidate to protect and/or regenerate the mesostriatal DA system in Parkinson disease (PD). Clinical trials with GDNF on PD patients are, however, so far inconclusive. Here, we review the current knowledge of GDNF and Ret signaling and function in the midbrain DA system, and their crosstalk with proteins and signaling pathways associated with PD.
AB - Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriatal DA system, the physiological functions of GDNF for the DA system are still unclear. Nevertheless, GDNF is still considered to be an excellent candidate to protect and/or regenerate the mesostriatal DA system in Parkinson disease (PD). Clinical trials with GDNF on PD patients are, however, so far inconclusive. Here, we review the current knowledge of GDNF and Ret signaling and function in the midbrain DA system, and their crosstalk with proteins and signaling pathways associated with PD.
U2 - 10.1016/j.febslet.2015.11.006
DO - 10.1016/j.febslet.2015.11.006
M3 - SCORING: Journal article
C2 - 26555190
VL - 589
SP - 3760
EP - 3772
JO - FEBS LETT
JF - FEBS LETT
SN - 0014-5793
IS - 24 Pt A
ER -