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FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo

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FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo. / Kuhn, Christian; Menke, Maja; Senger, Frauke; Mack, Claudia; Dierck, Franziska; Hille, Susanne; Schmidt, Inga; Brunke, Gabriele; Bünger, Pia; Schmiedel, Nesrin; Will, Rainer; Sossalla, Samuel; Frank, Derk; Eschenhagen, Thomas; Carrier, Lucie; Lüllmann-Rauch, Renate; Yusuf, Ashraf; Frey, Norbert.

In: JACC-BASIC TRANSL SC, Vol. 6, No. 4, 04.2021, p. 365-380.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kuhn, C, Menke, M, Senger, F, Mack, C, Dierck, F, Hille, S, Schmidt, I, Brunke, G, Bünger, P, Schmiedel, N, Will, R, Sossalla, S, Frank, D, Eschenhagen, T, Carrier, L, Lüllmann-Rauch, R, Yusuf, A & Frey, N 2021, 'FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo', JACC-BASIC TRANSL SC, vol. 6, no. 4, pp. 365-380. https://doi.org/10.1016/j.jacbts.2021.01.001

APA

Kuhn, C., Menke, M., Senger, F., Mack, C., Dierck, F., Hille, S., Schmidt, I., Brunke, G., Bünger, P., Schmiedel, N., Will, R., Sossalla, S., Frank, D., Eschenhagen, T., Carrier, L., Lüllmann-Rauch, R., Yusuf, A., & Frey, N. (2021). FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo. JACC-BASIC TRANSL SC, 6(4), 365-380. https://doi.org/10.1016/j.jacbts.2021.01.001

Vancouver

Kuhn C, Menke M, Senger F, Mack C, Dierck F, Hille S et al. FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo. JACC-BASIC TRANSL SC. 2021 Apr;6(4):365-380. https://doi.org/10.1016/j.jacbts.2021.01.001

Bibtex

@article{77093b1f508d411fa167a6f657877a71,
title = "FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo",
abstract = "Autophagy is a cellular degradation process that has been implicated in diverse disease processes. The authors provide evidence that FYCO1, a component of the autophagic machinery, is essential for adaptation to cardiac stress. Although the absence of FYCO1 does not affect basal autophagy in isolated cardiomyocytes, it abolishes induction of autophagy after glucose deprivation. Likewise, Fyco1-deficient mice subjected to starvation or pressure overload are unable to respond with induction of autophagy and develop impaired cardiac function. FYCO1 overexpression leads to induction of autophagy in isolated cardiomyocytes and transgenic mouse hearts, thereby rescuing cardiac dysfunction in response to biomechanical stress.",
author = "Christian Kuhn and Maja Menke and Frauke Senger and Claudia Mack and Franziska Dierck and Susanne Hille and Inga Schmidt and Gabriele Brunke and Pia B{\"u}nger and Nesrin Schmiedel and Rainer Will and Samuel Sossalla and Derk Frank and Thomas Eschenhagen and Lucie Carrier and Renate L{\"u}llmann-Rauch and Ashraf Yusuf and Norbert Frey",
year = "2021",
month = apr,
doi = "10.1016/j.jacbts.2021.01.001",
language = "English",
volume = "6",
pages = "365--380",
journal = "JACC-BASIC TRANSL SC",
issn = "2452-302X",
publisher = "Elsevier Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo

AU - Kuhn, Christian

AU - Menke, Maja

AU - Senger, Frauke

AU - Mack, Claudia

AU - Dierck, Franziska

AU - Hille, Susanne

AU - Schmidt, Inga

AU - Brunke, Gabriele

AU - Bünger, Pia

AU - Schmiedel, Nesrin

AU - Will, Rainer

AU - Sossalla, Samuel

AU - Frank, Derk

AU - Eschenhagen, Thomas

AU - Carrier, Lucie

AU - Lüllmann-Rauch, Renate

AU - Yusuf, Ashraf

AU - Frey, Norbert

PY - 2021/4

Y1 - 2021/4

N2 - Autophagy is a cellular degradation process that has been implicated in diverse disease processes. The authors provide evidence that FYCO1, a component of the autophagic machinery, is essential for adaptation to cardiac stress. Although the absence of FYCO1 does not affect basal autophagy in isolated cardiomyocytes, it abolishes induction of autophagy after glucose deprivation. Likewise, Fyco1-deficient mice subjected to starvation or pressure overload are unable to respond with induction of autophagy and develop impaired cardiac function. FYCO1 overexpression leads to induction of autophagy in isolated cardiomyocytes and transgenic mouse hearts, thereby rescuing cardiac dysfunction in response to biomechanical stress.

AB - Autophagy is a cellular degradation process that has been implicated in diverse disease processes. The authors provide evidence that FYCO1, a component of the autophagic machinery, is essential for adaptation to cardiac stress. Although the absence of FYCO1 does not affect basal autophagy in isolated cardiomyocytes, it abolishes induction of autophagy after glucose deprivation. Likewise, Fyco1-deficient mice subjected to starvation or pressure overload are unable to respond with induction of autophagy and develop impaired cardiac function. FYCO1 overexpression leads to induction of autophagy in isolated cardiomyocytes and transgenic mouse hearts, thereby rescuing cardiac dysfunction in response to biomechanical stress.

U2 - 10.1016/j.jacbts.2021.01.001

DO - 10.1016/j.jacbts.2021.01.001

M3 - SCORING: Journal article

VL - 6

SP - 365

EP - 380

JO - JACC-BASIC TRANSL SC

JF - JACC-BASIC TRANSL SC

SN - 2452-302X

IS - 4

ER -