FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo
Standard
FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo. / Kuhn, Christian; Menke, Maja; Senger, Frauke; Mack, Claudia; Dierck, Franziska; Hille, Susanne; Schmidt, Inga; Brunke, Gabriele; Bünger, Pia; Schmiedel, Nesrin; Will, Rainer; Sossalla, Samuel; Frank, Derk; Eschenhagen, Thomas; Carrier, Lucie; Lüllmann-Rauch, Renate; Yusuf, Ashraf; Frey, Norbert.
in: JACC-BASIC TRANSL SC, Jahrgang 6, Nr. 4, 04.2021, S. 365-380.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo
AU - Kuhn, Christian
AU - Menke, Maja
AU - Senger, Frauke
AU - Mack, Claudia
AU - Dierck, Franziska
AU - Hille, Susanne
AU - Schmidt, Inga
AU - Brunke, Gabriele
AU - Bünger, Pia
AU - Schmiedel, Nesrin
AU - Will, Rainer
AU - Sossalla, Samuel
AU - Frank, Derk
AU - Eschenhagen, Thomas
AU - Carrier, Lucie
AU - Lüllmann-Rauch, Renate
AU - Yusuf, Ashraf
AU - Frey, Norbert
PY - 2021/4
Y1 - 2021/4
N2 - Autophagy is a cellular degradation process that has been implicated in diverse disease processes. The authors provide evidence that FYCO1, a component of the autophagic machinery, is essential for adaptation to cardiac stress. Although the absence of FYCO1 does not affect basal autophagy in isolated cardiomyocytes, it abolishes induction of autophagy after glucose deprivation. Likewise, Fyco1-deficient mice subjected to starvation or pressure overload are unable to respond with induction of autophagy and develop impaired cardiac function. FYCO1 overexpression leads to induction of autophagy in isolated cardiomyocytes and transgenic mouse hearts, thereby rescuing cardiac dysfunction in response to biomechanical stress.
AB - Autophagy is a cellular degradation process that has been implicated in diverse disease processes. The authors provide evidence that FYCO1, a component of the autophagic machinery, is essential for adaptation to cardiac stress. Although the absence of FYCO1 does not affect basal autophagy in isolated cardiomyocytes, it abolishes induction of autophagy after glucose deprivation. Likewise, Fyco1-deficient mice subjected to starvation or pressure overload are unable to respond with induction of autophagy and develop impaired cardiac function. FYCO1 overexpression leads to induction of autophagy in isolated cardiomyocytes and transgenic mouse hearts, thereby rescuing cardiac dysfunction in response to biomechanical stress.
U2 - 10.1016/j.jacbts.2021.01.001
DO - 10.1016/j.jacbts.2021.01.001
M3 - SCORING: Journal article
VL - 6
SP - 365
EP - 380
JO - JACC-BASIC TRANSL SC
JF - JACC-BASIC TRANSL SC
SN - 2452-302X
IS - 4
ER -