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FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats.

Standard

FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats. / Ghebremariam, Yohannes T; Yamada, Keisuke; Lee, Jerry C; Johnson, Christine L C; Atzler, Dorothee; Anderssohn, Maike; Agrawal, Rani; Higgins, John P; Patterson, Andrew J; Böger, Rainer; Cooke, John P.

In: PLOS ONE, Vol. 8, No. 4, 4, 2013, p. 60653.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ghebremariam, YT, Yamada, K, Lee, JC, Johnson, CLC, Atzler, D, Anderssohn, M, Agrawal, R, Higgins, JP, Patterson, AJ, Böger, R & Cooke, JP 2013, 'FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats.', PLOS ONE, vol. 8, no. 4, 4, pp. 60653. https://doi.org/10.1371/journal.pone.0060653

APA

Ghebremariam, Y. T., Yamada, K., Lee, J. C., Johnson, C. L. C., Atzler, D., Anderssohn, M., Agrawal, R., Higgins, J. P., Patterson, A. J., Böger, R., & Cooke, J. P. (2013). FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats. PLOS ONE, 8(4), 60653. [4]. https://doi.org/10.1371/journal.pone.0060653

Vancouver

Ghebremariam YT, Yamada K, Lee JC, Johnson CLC, Atzler D, Anderssohn M et al. FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats. PLOS ONE. 2013;8(4):60653. 4. https://doi.org/10.1371/journal.pone.0060653

Bibtex

@article{a5f0ee7c47e14a43b986a0bb80d1156c,
title = "FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats.",
abstract = "Genetic and pharmacological studies have shown that impairment of the nitric oxide (NO) synthase (NOS) pathway is associated with hypertension and insulin-resistance (IR). In addition, inhibition of NOS by the endogenous inhibitor, asymmetric dimethylarginine (ADMA), may also result in hypertension and IR. On the other hand, overexpression of dimethylarginine dimethylaminohydrolase (DDAH), an enzyme that metabolizes ADMA, in mice is associated with lower ADMA, increased NO and enhanced insulin sensitivity. Since DDAH carries a farnesoid X receptor (FXR)-responsive element, we aimed to upregulate its expression by an FXR-agonist, INT-747, and evaluate its effect on blood pressure and insulin sensitivity.",
author = "Ghebremariam, {Yohannes T} and Keisuke Yamada and Lee, {Jerry C} and Johnson, {Christine L C} and Dorothee Atzler and Maike Anderssohn and Rani Agrawal and Higgins, {John P} and Patterson, {Andrew J} and Rainer B{\"o}ger and Cooke, {John P}",
year = "2013",
doi = "10.1371/journal.pone.0060653",
language = "English",
volume = "8",
pages = "60653",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

RIS

TY - JOUR

T1 - FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats.

AU - Ghebremariam, Yohannes T

AU - Yamada, Keisuke

AU - Lee, Jerry C

AU - Johnson, Christine L C

AU - Atzler, Dorothee

AU - Anderssohn, Maike

AU - Agrawal, Rani

AU - Higgins, John P

AU - Patterson, Andrew J

AU - Böger, Rainer

AU - Cooke, John P

PY - 2013

Y1 - 2013

N2 - Genetic and pharmacological studies have shown that impairment of the nitric oxide (NO) synthase (NOS) pathway is associated with hypertension and insulin-resistance (IR). In addition, inhibition of NOS by the endogenous inhibitor, asymmetric dimethylarginine (ADMA), may also result in hypertension and IR. On the other hand, overexpression of dimethylarginine dimethylaminohydrolase (DDAH), an enzyme that metabolizes ADMA, in mice is associated with lower ADMA, increased NO and enhanced insulin sensitivity. Since DDAH carries a farnesoid X receptor (FXR)-responsive element, we aimed to upregulate its expression by an FXR-agonist, INT-747, and evaluate its effect on blood pressure and insulin sensitivity.

AB - Genetic and pharmacological studies have shown that impairment of the nitric oxide (NO) synthase (NOS) pathway is associated with hypertension and insulin-resistance (IR). In addition, inhibition of NOS by the endogenous inhibitor, asymmetric dimethylarginine (ADMA), may also result in hypertension and IR. On the other hand, overexpression of dimethylarginine dimethylaminohydrolase (DDAH), an enzyme that metabolizes ADMA, in mice is associated with lower ADMA, increased NO and enhanced insulin sensitivity. Since DDAH carries a farnesoid X receptor (FXR)-responsive element, we aimed to upregulate its expression by an FXR-agonist, INT-747, and evaluate its effect on blood pressure and insulin sensitivity.

U2 - 10.1371/journal.pone.0060653

DO - 10.1371/journal.pone.0060653

M3 - SCORING: Journal article

VL - 8

SP - 60653

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 4

M1 - 4

ER -