FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats.
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FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats. / Ghebremariam, Yohannes T; Yamada, Keisuke; Lee, Jerry C; Johnson, Christine L C; Atzler, Dorothee; Anderssohn, Maike; Agrawal, Rani; Higgins, John P; Patterson, Andrew J; Böger, Rainer; Cooke, John P.
in: PLOS ONE, Jahrgang 8, Nr. 4, 4, 2013, S. 60653.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats.
AU - Ghebremariam, Yohannes T
AU - Yamada, Keisuke
AU - Lee, Jerry C
AU - Johnson, Christine L C
AU - Atzler, Dorothee
AU - Anderssohn, Maike
AU - Agrawal, Rani
AU - Higgins, John P
AU - Patterson, Andrew J
AU - Böger, Rainer
AU - Cooke, John P
PY - 2013
Y1 - 2013
N2 - Genetic and pharmacological studies have shown that impairment of the nitric oxide (NO) synthase (NOS) pathway is associated with hypertension and insulin-resistance (IR). In addition, inhibition of NOS by the endogenous inhibitor, asymmetric dimethylarginine (ADMA), may also result in hypertension and IR. On the other hand, overexpression of dimethylarginine dimethylaminohydrolase (DDAH), an enzyme that metabolizes ADMA, in mice is associated with lower ADMA, increased NO and enhanced insulin sensitivity. Since DDAH carries a farnesoid X receptor (FXR)-responsive element, we aimed to upregulate its expression by an FXR-agonist, INT-747, and evaluate its effect on blood pressure and insulin sensitivity.
AB - Genetic and pharmacological studies have shown that impairment of the nitric oxide (NO) synthase (NOS) pathway is associated with hypertension and insulin-resistance (IR). In addition, inhibition of NOS by the endogenous inhibitor, asymmetric dimethylarginine (ADMA), may also result in hypertension and IR. On the other hand, overexpression of dimethylarginine dimethylaminohydrolase (DDAH), an enzyme that metabolizes ADMA, in mice is associated with lower ADMA, increased NO and enhanced insulin sensitivity. Since DDAH carries a farnesoid X receptor (FXR)-responsive element, we aimed to upregulate its expression by an FXR-agonist, INT-747, and evaluate its effect on blood pressure and insulin sensitivity.
U2 - 10.1371/journal.pone.0060653
DO - 10.1371/journal.pone.0060653
M3 - SCORING: Journal article
VL - 8
SP - 60653
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 4
M1 - 4
ER -