Functional development of γδ T cells

Immo Prinz; Bruno Silva-Santos; Daniel J Pennington

doi:10.1002/eji.201343759

Functional development of γδ T cells

Standard

Functional development of γδ T cells. / Prinz, Immo; Silva-Santos, Bruno; Pennington, Daniel J.

In: EUR J IMMUNOL, Vol. 43, No. 8, 08.2013, p. 1988-94.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Prinz, I, Silva-Santos, B & Pennington, DJ 2013, 'Functional development of γδ T cells', EUR J IMMUNOL, vol. 43, no. 8, pp. 1988-94. https://doi.org/10.1002/eji.201343759

APA

Prinz, I., Silva-Santos, B., & Pennington, D. J. (2013). Functional development of γδ T cells. EUR J IMMUNOL, 43(8), 1988-94. https://doi.org/10.1002/eji.201343759

Vancouver

Prinz I, Silva-Santos B, Pennington DJ. Functional development of γδ T cells. EUR J IMMUNOL. 2013 Aug;43(8):1988-94. https://doi.org/10.1002/eji.201343759

Bibtex

@article{c3414ed316b141698e4bffb8de0dfdf3,

title = "Functional development of γδ T cells",

abstract = "The thymus generates T cells that are generally functionally immature and thus require peripheral activation for differentiation into effector lymphocytes. Notable exceptions to this rule are murine γδ T cells, many of which have been shown to acquire their functional potential during thymic development from late embryonic stages. Here, we review the underlying ontogenic processes and molecular differentiation mechanisms of murine γδ T cells, focusing on the transcriptional control of IFN-γ and IL-17 expression. We propose that functional commitment of γδ T cells occurs in {"}developmental windows{"} defined by the molecular composition of the thymic microenvironment, such as T-cell receptor (TCR), TCR coreceptor ligands, and cytokines. We further discuss the similarities and particularities of functional development of γδ T cells in mice and humans, while highlighting some key unresolved issues for future investigation. ",

keywords = "Animals, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Cell Differentiation, Cell Lineage, Humans, Interferon-gamma/biosynthesis, Interleukin-17/biosynthesis, Mice, Receptors, Antigen, T-Cell, gamma-delta/analysis, T-Lymphocyte Subsets/immunology, Thymus Gland/embryology, Transcription, Genetic",

author = "Immo Prinz and Bruno Silva-Santos and Pennington, {Daniel J}",

note = "{\textcopyright} 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2013",

month = aug,

doi = "10.1002/eji.201343759",

language = "English",

volume = "43",

pages = "1988--94",

journal = "EUR J IMMUNOL",

issn = "0014-2980",

publisher = "Wiley-VCH Verlag GmbH",

number = "8",

}

RIS

TY - JOUR

T1 - Functional development of γδ T cells

AU - Prinz, Immo

AU - Silva-Santos, Bruno

AU - Pennington, Daniel J

PY - 2013/8

Y1 - 2013/8

N2 - The thymus generates T cells that are generally functionally immature and thus require peripheral activation for differentiation into effector lymphocytes. Notable exceptions to this rule are murine γδ T cells, many of which have been shown to acquire their functional potential during thymic development from late embryonic stages. Here, we review the underlying ontogenic processes and molecular differentiation mechanisms of murine γδ T cells, focusing on the transcriptional control of IFN-γ and IL-17 expression. We propose that functional commitment of γδ T cells occurs in "developmental windows" defined by the molecular composition of the thymic microenvironment, such as T-cell receptor (TCR), TCR coreceptor ligands, and cytokines. We further discuss the similarities and particularities of functional development of γδ T cells in mice and humans, while highlighting some key unresolved issues for future investigation.

AB - The thymus generates T cells that are generally functionally immature and thus require peripheral activation for differentiation into effector lymphocytes. Notable exceptions to this rule are murine γδ T cells, many of which have been shown to acquire their functional potential during thymic development from late embryonic stages. Here, we review the underlying ontogenic processes and molecular differentiation mechanisms of murine γδ T cells, focusing on the transcriptional control of IFN-γ and IL-17 expression. We propose that functional commitment of γδ T cells occurs in "developmental windows" defined by the molecular composition of the thymic microenvironment, such as T-cell receptor (TCR), TCR coreceptor ligands, and cytokines. We further discuss the similarities and particularities of functional development of γδ T cells in mice and humans, while highlighting some key unresolved issues for future investigation.

KW - Animals

KW - CD4-Positive T-Lymphocytes/immunology

KW - CD8-Positive T-Lymphocytes/immunology

KW - Cell Differentiation

KW - Cell Lineage

KW - Humans

KW - Interferon-gamma/biosynthesis

KW - Interleukin-17/biosynthesis

KW - Mice

KW - Receptors, Antigen, T-Cell, gamma-delta/analysis

KW - T-Lymphocyte Subsets/immunology

KW - Thymus Gland/embryology

KW - Transcription, Genetic

U2 - 10.1002/eji.201343759

DO - 10.1002/eji.201343759

M3 - SCORING: Review article

C2 - 23928962

VL - 43

SP - 1988

EP - 1994

JO - EUR J IMMUNOL

JF - EUR J IMMUNOL

SN - 0014-2980

IS - 8

ER -