Functional development of γδ T cells
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Functional development of γδ T cells. / Prinz, Immo; Silva-Santos, Bruno; Pennington, Daniel J.
in: EUR J IMMUNOL, Jahrgang 43, Nr. 8, 08.2013, S. 1988-94.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Functional development of γδ T cells
AU - Prinz, Immo
AU - Silva-Santos, Bruno
AU - Pennington, Daniel J
N1 - © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2013/8
Y1 - 2013/8
N2 - The thymus generates T cells that are generally functionally immature and thus require peripheral activation for differentiation into effector lymphocytes. Notable exceptions to this rule are murine γδ T cells, many of which have been shown to acquire their functional potential during thymic development from late embryonic stages. Here, we review the underlying ontogenic processes and molecular differentiation mechanisms of murine γδ T cells, focusing on the transcriptional control of IFN-γ and IL-17 expression. We propose that functional commitment of γδ T cells occurs in "developmental windows" defined by the molecular composition of the thymic microenvironment, such as T-cell receptor (TCR), TCR coreceptor ligands, and cytokines. We further discuss the similarities and particularities of functional development of γδ T cells in mice and humans, while highlighting some key unresolved issues for future investigation.
AB - The thymus generates T cells that are generally functionally immature and thus require peripheral activation for differentiation into effector lymphocytes. Notable exceptions to this rule are murine γδ T cells, many of which have been shown to acquire their functional potential during thymic development from late embryonic stages. Here, we review the underlying ontogenic processes and molecular differentiation mechanisms of murine γδ T cells, focusing on the transcriptional control of IFN-γ and IL-17 expression. We propose that functional commitment of γδ T cells occurs in "developmental windows" defined by the molecular composition of the thymic microenvironment, such as T-cell receptor (TCR), TCR coreceptor ligands, and cytokines. We further discuss the similarities and particularities of functional development of γδ T cells in mice and humans, while highlighting some key unresolved issues for future investigation.
KW - Animals
KW - CD4-Positive T-Lymphocytes/immunology
KW - CD8-Positive T-Lymphocytes/immunology
KW - Cell Differentiation
KW - Cell Lineage
KW - Humans
KW - Interferon-gamma/biosynthesis
KW - Interleukin-17/biosynthesis
KW - Mice
KW - Receptors, Antigen, T-Cell, gamma-delta/analysis
KW - T-Lymphocyte Subsets/immunology
KW - Thymus Gland/embryology
KW - Transcription, Genetic
U2 - 10.1002/eji.201343759
DO - 10.1002/eji.201343759
M3 - SCORING: Review article
C2 - 23928962
VL - 43
SP - 1988
EP - 1994
JO - EUR J IMMUNOL
JF - EUR J IMMUNOL
SN - 0014-2980
IS - 8
ER -