Fucoidans as potential inhibitors of HIV-1
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Fucoidans as potential inhibitors of HIV-1. / Prokofjeva, Maria M; Imbs, Tatyana I; Shevchenko, Natalya M; Spirin, Pavel V; Horn, Stefan; Fehse, Boris; Zvyagintseva, Tatyana N; Prassolov, Vladimir S.
In: MAR DRUGS, Vol. 11, No. 8, 01.01.2013, p. 3000-14.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Fucoidans as potential inhibitors of HIV-1
AU - Prokofjeva, Maria M
AU - Imbs, Tatyana I
AU - Shevchenko, Natalya M
AU - Spirin, Pavel V
AU - Horn, Stefan
AU - Fehse, Boris
AU - Zvyagintseva, Tatyana N
AU - Prassolov, Vladimir S
PY - 2013/1/1
Y1 - 2013/1/1
N2 - The antiviral activity of different structure fucoidans (α-l-fucans and galactofucans) was studied using two model viral systems based on a lentiviral vectors and a replication competent Moloney murine leukemia virus (Mo-MuLV). It was found that investigated fucoidans have no cytotoxic effects on Jurkat and SC-1cell at the concentration range of 0.001-100 µg/mL. Fucoidans with different efficiency suppressed transduction of Jurkat cell line by pseudo-HIV-1 particles carrying the envelope protein of HIV-1 and infection of SC-1 cells by Mo-MuLV. According to our data, all natural fucoidans can be considered as potential anti-HIV agents regardless of their carbohydrate backbone and degree of sulfating, since their activity is shown at low concentrations (0.001-0.05 µg/mL). High molecular weight fucoidans isolated from Saccharina cichorioides (1.3-α-l-fucan), and S. japonica (galactofucan) were the most effective inhibitors.
AB - The antiviral activity of different structure fucoidans (α-l-fucans and galactofucans) was studied using two model viral systems based on a lentiviral vectors and a replication competent Moloney murine leukemia virus (Mo-MuLV). It was found that investigated fucoidans have no cytotoxic effects on Jurkat and SC-1cell at the concentration range of 0.001-100 µg/mL. Fucoidans with different efficiency suppressed transduction of Jurkat cell line by pseudo-HIV-1 particles carrying the envelope protein of HIV-1 and infection of SC-1 cells by Mo-MuLV. According to our data, all natural fucoidans can be considered as potential anti-HIV agents regardless of their carbohydrate backbone and degree of sulfating, since their activity is shown at low concentrations (0.001-0.05 µg/mL). High molecular weight fucoidans isolated from Saccharina cichorioides (1.3-α-l-fucan), and S. japonica (galactofucan) were the most effective inhibitors.
KW - Anti-HIV Agents
KW - Antiviral Agents
KW - Cell Line
KW - Dose-Response Relationship, Drug
KW - Genetic Vectors
KW - HIV-1
KW - Humans
KW - Jurkat Cells
KW - Lentivirus
KW - Molecular Weight
KW - Moloney murine leukemia virus
KW - Phaeophyta
KW - Polysaccharides
U2 - 10.3390/md11083000
DO - 10.3390/md11083000
M3 - SCORING: Journal article
C2 - 23966033
VL - 11
SP - 3000
EP - 3014
JO - MAR DRUGS
JF - MAR DRUGS
SN - 1660-3397
IS - 8
ER -