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Fucoidans as potential inhibitors of HIV-1

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Fucoidans as potential inhibitors of HIV-1. / Prokofjeva, Maria M; Imbs, Tatyana I; Shevchenko, Natalya M; Spirin, Pavel V; Horn, Stefan; Fehse, Boris; Zvyagintseva, Tatyana N; Prassolov, Vladimir S.

in: MAR DRUGS, Jahrgang 11, Nr. 8, 01.01.2013, S. 3000-14.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Prokofjeva, MM, Imbs, TI, Shevchenko, NM, Spirin, PV, Horn, S, Fehse, B, Zvyagintseva, TN & Prassolov, VS 2013, 'Fucoidans as potential inhibitors of HIV-1', MAR DRUGS, Jg. 11, Nr. 8, S. 3000-14. https://doi.org/10.3390/md11083000

APA

Prokofjeva, M. M., Imbs, T. I., Shevchenko, N. M., Spirin, P. V., Horn, S., Fehse, B., Zvyagintseva, T. N., & Prassolov, V. S. (2013). Fucoidans as potential inhibitors of HIV-1. MAR DRUGS, 11(8), 3000-14. https://doi.org/10.3390/md11083000

Vancouver

Prokofjeva MM, Imbs TI, Shevchenko NM, Spirin PV, Horn S, Fehse B et al. Fucoidans as potential inhibitors of HIV-1. MAR DRUGS. 2013 Jan 1;11(8):3000-14. https://doi.org/10.3390/md11083000

Bibtex

@article{29e32ef4111f494da2684793b4e5f4a7,
title = "Fucoidans as potential inhibitors of HIV-1",
abstract = "The antiviral activity of different structure fucoidans (α-l-fucans and galactofucans) was studied using two model viral systems based on a lentiviral vectors and a replication competent Moloney murine leukemia virus (Mo-MuLV). It was found that investigated fucoidans have no cytotoxic effects on Jurkat and SC-1cell at the concentration range of 0.001-100 µg/mL. Fucoidans with different efficiency suppressed transduction of Jurkat cell line by pseudo-HIV-1 particles carrying the envelope protein of HIV-1 and infection of SC-1 cells by Mo-MuLV. According to our data, all natural fucoidans can be considered as potential anti-HIV agents regardless of their carbohydrate backbone and degree of sulfating, since their activity is shown at low concentrations (0.001-0.05 µg/mL). High molecular weight fucoidans isolated from Saccharina cichorioides (1.3-α-l-fucan), and S. japonica (galactofucan) were the most effective inhibitors.",
keywords = "Anti-HIV Agents, Antiviral Agents, Cell Line, Dose-Response Relationship, Drug, Genetic Vectors, HIV-1, Humans, Jurkat Cells, Lentivirus, Molecular Weight, Moloney murine leukemia virus, Phaeophyta, Polysaccharides",
author = "Prokofjeva, {Maria M} and Imbs, {Tatyana I} and Shevchenko, {Natalya M} and Spirin, {Pavel V} and Stefan Horn and Boris Fehse and Zvyagintseva, {Tatyana N} and Prassolov, {Vladimir S}",
year = "2013",
month = jan,
day = "1",
doi = "10.3390/md11083000",
language = "English",
volume = "11",
pages = "3000--14",
journal = "MAR DRUGS",
issn = "1660-3397",
publisher = "MDPI AG",
number = "8",

}

RIS

TY - JOUR

T1 - Fucoidans as potential inhibitors of HIV-1

AU - Prokofjeva, Maria M

AU - Imbs, Tatyana I

AU - Shevchenko, Natalya M

AU - Spirin, Pavel V

AU - Horn, Stefan

AU - Fehse, Boris

AU - Zvyagintseva, Tatyana N

AU - Prassolov, Vladimir S

PY - 2013/1/1

Y1 - 2013/1/1

N2 - The antiviral activity of different structure fucoidans (α-l-fucans and galactofucans) was studied using two model viral systems based on a lentiviral vectors and a replication competent Moloney murine leukemia virus (Mo-MuLV). It was found that investigated fucoidans have no cytotoxic effects on Jurkat and SC-1cell at the concentration range of 0.001-100 µg/mL. Fucoidans with different efficiency suppressed transduction of Jurkat cell line by pseudo-HIV-1 particles carrying the envelope protein of HIV-1 and infection of SC-1 cells by Mo-MuLV. According to our data, all natural fucoidans can be considered as potential anti-HIV agents regardless of their carbohydrate backbone and degree of sulfating, since their activity is shown at low concentrations (0.001-0.05 µg/mL). High molecular weight fucoidans isolated from Saccharina cichorioides (1.3-α-l-fucan), and S. japonica (galactofucan) were the most effective inhibitors.

AB - The antiviral activity of different structure fucoidans (α-l-fucans and galactofucans) was studied using two model viral systems based on a lentiviral vectors and a replication competent Moloney murine leukemia virus (Mo-MuLV). It was found that investigated fucoidans have no cytotoxic effects on Jurkat and SC-1cell at the concentration range of 0.001-100 µg/mL. Fucoidans with different efficiency suppressed transduction of Jurkat cell line by pseudo-HIV-1 particles carrying the envelope protein of HIV-1 and infection of SC-1 cells by Mo-MuLV. According to our data, all natural fucoidans can be considered as potential anti-HIV agents regardless of their carbohydrate backbone and degree of sulfating, since their activity is shown at low concentrations (0.001-0.05 µg/mL). High molecular weight fucoidans isolated from Saccharina cichorioides (1.3-α-l-fucan), and S. japonica (galactofucan) were the most effective inhibitors.

KW - Anti-HIV Agents

KW - Antiviral Agents

KW - Cell Line

KW - Dose-Response Relationship, Drug

KW - Genetic Vectors

KW - HIV-1

KW - Humans

KW - Jurkat Cells

KW - Lentivirus

KW - Molecular Weight

KW - Moloney murine leukemia virus

KW - Phaeophyta

KW - Polysaccharides

U2 - 10.3390/md11083000

DO - 10.3390/md11083000

M3 - SCORING: Journal article

C2 - 23966033

VL - 11

SP - 3000

EP - 3014

JO - MAR DRUGS

JF - MAR DRUGS

SN - 1660-3397

IS - 8

ER -