Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity

Jan Klatt; Carola E Gerich; Alexander Gröbe; Jörg Opitz; Jürgen Schreiber; Henning Hanken; Georg Salomon; Max Heiland; Lan Kluwe; Marco Blessmann

doi:10.1016/j.jcms.2013.12.004

Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity

Standard

Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity. / Klatt, Jan; Gerich, Carola E; Gröbe, Alexander; Opitz, Jörg; Schreiber, Jürgen; Hanken, Henning; Salomon, Georg; Heiland, Max; Kluwe, Lan ; Blessmann, Marco.

In: J CRANIO MAXILL SURG, Vol. 42, No. 6, 2014, p. 852-854.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Klatt, J, Gerich, CE, Gröbe, A, Opitz, J, Schreiber, J, Hanken, H, Salomon, G, Heiland, M, Kluwe, L & Blessmann, M 2014, 'Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity', J CRANIO MAXILL SURG, vol. 42, no. 6, pp. 852-854. https://doi.org/10.1016/j.jcms.2013.12.004

APA

Klatt, J., Gerich, C. E., Gröbe, A., Opitz, J., Schreiber, J., Hanken, H., Salomon, G., Heiland, M., Kluwe, L., & Blessmann, M. (2014). Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity. J CRANIO MAXILL SURG, 42(6), 852-854. https://doi.org/10.1016/j.jcms.2013.12.004

Vancouver

Klatt J, Gerich CE, Gröbe A, Opitz J, Schreiber J, Hanken H et al. Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity. J CRANIO MAXILL SURG. 2014;42(6):852-854. https://doi.org/10.1016/j.jcms.2013.12.004

Bibtex

@article{ba9915ab2b2e4691b21983da29fc7066,

title = "Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity",

abstract = "Early detection and complete resection of oral carcinomas is of crucial importance for patient survival. This could be significantly improved by developing a non-invasive, sensitive and real-time detection technique. Time-resolved autofluorescence measurement is state-of-the-art technology originally developed for non-destructive inspection of material. In this study, we measured time-resolved autofluorescence in tumours and healthy tissues of the oral cavity ex vivo and calculated the corresponding fractal dimension which was significantly higher in tumours than in healthy tissues (1.8 vs. 1.6, P < 0.001, unpaired t-test) with non-overlapping 95% confidential intervals 1.88-1.84 and 1.57-1.69, respectively. Very high specificity (86%) could be reached at 100% sensitivity. The area under the curve was 99%, further suggesting the superior prediction potential of fractal dimension based on time-resolved autofluorescence spectra.",

author = "Jan Klatt and Gerich, {Carola E} and Alexander Gr{\"o}be and J{\"o}rg Opitz and J{\"u}rgen Schreiber and Henning Hanken and Georg Salomon and Max Heiland and Lan Kluwe and Marco Blessmann",

note = "Lan Kluwe-nicht Neurologie? Nur MKG? ",

year = "2014",

doi = "10.1016/j.jcms.2013.12.004",

language = "English",

volume = "42",

pages = "852--854",

journal = "J CRANIO MAXILL SURG",

issn = "1010-5182",

publisher = "Elsevier",

number = "6",

}

RIS

TY - JOUR

T1 - Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity

AU - Klatt, Jan

AU - Gerich, Carola E

AU - Gröbe, Alexander

AU - Opitz, Jörg

AU - Schreiber, Jürgen

AU - Hanken, Henning

AU - Salomon, Georg

AU - Heiland, Max

AU - Kluwe, Lan

AU - Blessmann, Marco

N1 - Lan Kluwe-nicht Neurologie? Nur MKG?

PY - 2014

Y1 - 2014

N2 - Early detection and complete resection of oral carcinomas is of crucial importance for patient survival. This could be significantly improved by developing a non-invasive, sensitive and real-time detection technique. Time-resolved autofluorescence measurement is state-of-the-art technology originally developed for non-destructive inspection of material. In this study, we measured time-resolved autofluorescence in tumours and healthy tissues of the oral cavity ex vivo and calculated the corresponding fractal dimension which was significantly higher in tumours than in healthy tissues (1.8 vs. 1.6, P < 0.001, unpaired t-test) with non-overlapping 95% confidential intervals 1.88-1.84 and 1.57-1.69, respectively. Very high specificity (86%) could be reached at 100% sensitivity. The area under the curve was 99%, further suggesting the superior prediction potential of fractal dimension based on time-resolved autofluorescence spectra.

AB - Early detection and complete resection of oral carcinomas is of crucial importance for patient survival. This could be significantly improved by developing a non-invasive, sensitive and real-time detection technique. Time-resolved autofluorescence measurement is state-of-the-art technology originally developed for non-destructive inspection of material. In this study, we measured time-resolved autofluorescence in tumours and healthy tissues of the oral cavity ex vivo and calculated the corresponding fractal dimension which was significantly higher in tumours than in healthy tissues (1.8 vs. 1.6, P < 0.001, unpaired t-test) with non-overlapping 95% confidential intervals 1.88-1.84 and 1.57-1.69, respectively. Very high specificity (86%) could be reached at 100% sensitivity. The area under the curve was 99%, further suggesting the superior prediction potential of fractal dimension based on time-resolved autofluorescence spectra.

U2 - 10.1016/j.jcms.2013.12.004

DO - 10.1016/j.jcms.2013.12.004

M3 - SCORING: Journal article

C2 - 24444757

VL - 42

SP - 852

EP - 854

JO - J CRANIO MAXILL SURG

JF - J CRANIO MAXILL SURG

SN - 1010-5182

IS - 6

ER -