Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity
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Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity. / Klatt, Jan; Gerich, Carola E; Gröbe, Alexander; Opitz, Jörg; Schreiber, Jürgen; Hanken, Henning; Salomon, Georg; Heiland, Max; Kluwe, Lan; Blessmann, Marco.
in: J CRANIO MAXILL SURG, Jahrgang 42, Nr. 6, 2014, S. 852-854.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Fractal dimension of time-resolved autofluorescence discriminates tumour from healthy tissues in the oral cavity
AU - Klatt, Jan
AU - Gerich, Carola E
AU - Gröbe, Alexander
AU - Opitz, Jörg
AU - Schreiber, Jürgen
AU - Hanken, Henning
AU - Salomon, Georg
AU - Heiland, Max
AU - Kluwe, Lan
AU - Blessmann, Marco
N1 - Lan Kluwe-nicht Neurologie? Nur MKG?
PY - 2014
Y1 - 2014
N2 - Early detection and complete resection of oral carcinomas is of crucial importance for patient survival. This could be significantly improved by developing a non-invasive, sensitive and real-time detection technique. Time-resolved autofluorescence measurement is state-of-the-art technology originally developed for non-destructive inspection of material. In this study, we measured time-resolved autofluorescence in tumours and healthy tissues of the oral cavity ex vivo and calculated the corresponding fractal dimension which was significantly higher in tumours than in healthy tissues (1.8 vs. 1.6, P < 0.001, unpaired t-test) with non-overlapping 95% confidential intervals 1.88-1.84 and 1.57-1.69, respectively. Very high specificity (86%) could be reached at 100% sensitivity. The area under the curve was 99%, further suggesting the superior prediction potential of fractal dimension based on time-resolved autofluorescence spectra.
AB - Early detection and complete resection of oral carcinomas is of crucial importance for patient survival. This could be significantly improved by developing a non-invasive, sensitive and real-time detection technique. Time-resolved autofluorescence measurement is state-of-the-art technology originally developed for non-destructive inspection of material. In this study, we measured time-resolved autofluorescence in tumours and healthy tissues of the oral cavity ex vivo and calculated the corresponding fractal dimension which was significantly higher in tumours than in healthy tissues (1.8 vs. 1.6, P < 0.001, unpaired t-test) with non-overlapping 95% confidential intervals 1.88-1.84 and 1.57-1.69, respectively. Very high specificity (86%) could be reached at 100% sensitivity. The area under the curve was 99%, further suggesting the superior prediction potential of fractal dimension based on time-resolved autofluorescence spectra.
U2 - 10.1016/j.jcms.2013.12.004
DO - 10.1016/j.jcms.2013.12.004
M3 - SCORING: Journal article
C2 - 24444757
VL - 42
SP - 852
EP - 854
JO - J CRANIO MAXILL SURG
JF - J CRANIO MAXILL SURG
SN - 1010-5182
IS - 6
ER -