FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency
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FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency. / Peiseler, Moritz; Sebode, Marcial; Franke, Björn; Wortmann, Frederike; Schwinge, Dorothee; Quaas, Alexander; Baron, Udo; Olek, Sven; Wiegard, Christiane; Lohse, Ansgar W.; Weiler-Normann, Christina; Schramm, Christoph; Herkel, Johannes.
In: J HEPATOL, Vol. 57, No. 1, 1, 07.2012, p. 125-132.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency
AU - Peiseler, Moritz
AU - Sebode, Marcial
AU - Franke, Björn
AU - Wortmann, Frederike
AU - Schwinge, Dorothee
AU - Quaas, Alexander
AU - Baron, Udo
AU - Olek, Sven
AU - Wiegard, Christiane
AU - Lohse, Ansgar W.
AU - Weiler-Normann, Christina
AU - Schramm, Christoph
AU - Herkel, Johannes
N1 - Copyright © 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
PY - 2012/7
Y1 - 2012/7
N2 - The pathogenesis of autoimmune hepatitis (AIH) is not understood, but it was suggested that AIH may be related to a numerical or functional impairment of CD4+CD25+FOXP3+ regulatory T cells (Treg), which are important mediators of immune tolerance to self-antigens. However, the role of Treg in AIH is not clear, since earlier studies reporting Treg impairment had used only CD25 as marker that cannot unambiguously distinguish Treg from activated effector T cells.
AB - The pathogenesis of autoimmune hepatitis (AIH) is not understood, but it was suggested that AIH may be related to a numerical or functional impairment of CD4+CD25+FOXP3+ regulatory T cells (Treg), which are important mediators of immune tolerance to self-antigens. However, the role of Treg in AIH is not clear, since earlier studies reporting Treg impairment had used only CD25 as marker that cannot unambiguously distinguish Treg from activated effector T cells.
KW - Adolescent
KW - Adult
KW - Aged
KW - CD4 Antigens
KW - Female
KW - Flow Cytometry
KW - Forkhead Transcription Factors
KW - Hepatitis, Autoimmune
KW - Humans
KW - Interleukin-2 Receptor alpha Subunit
KW - Lymphocyte Activation
KW - Lymphocyte Count
KW - Male
KW - Middle Aged
KW - T-Lymphocytes, Regulatory
KW - Young Adult
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.jhep.2012.02.029
DO - 10.1016/j.jhep.2012.02.029
M3 - SCORING: Journal article
C2 - 22425700
VL - 57
SP - 125
EP - 132
JO - J HEPATOL
JF - J HEPATOL
SN - 0168-8278
IS - 1
M1 - 1
ER -