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Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo

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Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo. / Joly, Anne-Laure; Liu, Sang; Dahlberg, Carin I M; Mailer, Reiner K W; Westerberg, Lisa S; Andersson, John.

In: J AUTOIMMUN, Vol. 63, 09.2015, p. 23-30.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Joly, A-L, Liu, S, Dahlberg, CIM, Mailer, RKW, Westerberg, LS & Andersson, J 2015, 'Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo', J AUTOIMMUN, vol. 63, pp. 23-30. https://doi.org/10.1016/j.jaut.2015.06.009

APA

Joly, A-L., Liu, S., Dahlberg, C. I. M., Mailer, R. K. W., Westerberg, L. S., & Andersson, J. (2015). Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo. J AUTOIMMUN, 63, 23-30. https://doi.org/10.1016/j.jaut.2015.06.009

Vancouver

Joly A-L, Liu S, Dahlberg CIM, Mailer RKW, Westerberg LS, Andersson J. Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo. J AUTOIMMUN. 2015 Sep;63:23-30. https://doi.org/10.1016/j.jaut.2015.06.009

Bibtex

@article{eb6b7f8bbc3e457c90f6bf3cbcfecf0f,
title = "Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo",
abstract = "The forkhead/winged-helix transcription factor FOXP3 confers suppressive ability to CD4(+)FOXP3(+) regulatory T (Treg) cells. Human Treg cells express several different isoforms of FOXP3 that differ in function. However, the regulation and functional consequences of FOXP3 isoform expression remains poorly understood. In order to study the function of the FOXP3Δ2Δ7 isoform in vivo we generated mice that exclusively expressed a Foxp3 isoform lacking exon 2 and 7. These mice exhibited multi-organ inflammation, increased cytokine production, global T cell activation, activation of antigen-presenting cells and B cell developmental defects, all features that are shared with mice completely deficient in FOXP3. Our results demonstrate that the mouse counterpart of human FOXP3Δ2Δ7 is unable to confer suppressive ability to Treg cells.",
keywords = "Animals, Exons, Forkhead Transcription Factors, Humans, Lymphocyte Activation, Mice, Mice, Transgenic, Protein Isoforms, T-Lymphocytes, Regulatory, Journal Article, Research Support, Non-U.S. Gov't",
author = "Anne-Laure Joly and Sang Liu and Dahlberg, {Carin I M} and Mailer, {Reiner K W} and Westerberg, {Lisa S} and John Andersson",
note = "Copyright {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",
year = "2015",
month = sep,
doi = "10.1016/j.jaut.2015.06.009",
language = "English",
volume = "63",
pages = "23--30",
journal = "J AUTOIMMUN",
issn = "0896-8411",
publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo

AU - Joly, Anne-Laure

AU - Liu, Sang

AU - Dahlberg, Carin I M

AU - Mailer, Reiner K W

AU - Westerberg, Lisa S

AU - Andersson, John

N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.

PY - 2015/9

Y1 - 2015/9

N2 - The forkhead/winged-helix transcription factor FOXP3 confers suppressive ability to CD4(+)FOXP3(+) regulatory T (Treg) cells. Human Treg cells express several different isoforms of FOXP3 that differ in function. However, the regulation and functional consequences of FOXP3 isoform expression remains poorly understood. In order to study the function of the FOXP3Δ2Δ7 isoform in vivo we generated mice that exclusively expressed a Foxp3 isoform lacking exon 2 and 7. These mice exhibited multi-organ inflammation, increased cytokine production, global T cell activation, activation of antigen-presenting cells and B cell developmental defects, all features that are shared with mice completely deficient in FOXP3. Our results demonstrate that the mouse counterpart of human FOXP3Δ2Δ7 is unable to confer suppressive ability to Treg cells.

AB - The forkhead/winged-helix transcription factor FOXP3 confers suppressive ability to CD4(+)FOXP3(+) regulatory T (Treg) cells. Human Treg cells express several different isoforms of FOXP3 that differ in function. However, the regulation and functional consequences of FOXP3 isoform expression remains poorly understood. In order to study the function of the FOXP3Δ2Δ7 isoform in vivo we generated mice that exclusively expressed a Foxp3 isoform lacking exon 2 and 7. These mice exhibited multi-organ inflammation, increased cytokine production, global T cell activation, activation of antigen-presenting cells and B cell developmental defects, all features that are shared with mice completely deficient in FOXP3. Our results demonstrate that the mouse counterpart of human FOXP3Δ2Δ7 is unable to confer suppressive ability to Treg cells.

KW - Animals

KW - Exons

KW - Forkhead Transcription Factors

KW - Humans

KW - Lymphocyte Activation

KW - Mice

KW - Mice, Transgenic

KW - Protein Isoforms

KW - T-Lymphocytes, Regulatory

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.jaut.2015.06.009

DO - 10.1016/j.jaut.2015.06.009

M3 - SCORING: Journal article

C2 - 26149776

VL - 63

SP - 23

EP - 30

JO - J AUTOIMMUN

JF - J AUTOIMMUN

SN - 0896-8411

ER -