Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo
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Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo. / Joly, Anne-Laure; Liu, Sang; Dahlberg, Carin I M; Mailer, Reiner K W; Westerberg, Lisa S; Andersson, John.
in: J AUTOIMMUN, Jahrgang 63, 09.2015, S. 23-30.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo
AU - Joly, Anne-Laure
AU - Liu, Sang
AU - Dahlberg, Carin I M
AU - Mailer, Reiner K W
AU - Westerberg, Lisa S
AU - Andersson, John
N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.
PY - 2015/9
Y1 - 2015/9
N2 - The forkhead/winged-helix transcription factor FOXP3 confers suppressive ability to CD4(+)FOXP3(+) regulatory T (Treg) cells. Human Treg cells express several different isoforms of FOXP3 that differ in function. However, the regulation and functional consequences of FOXP3 isoform expression remains poorly understood. In order to study the function of the FOXP3Δ2Δ7 isoform in vivo we generated mice that exclusively expressed a Foxp3 isoform lacking exon 2 and 7. These mice exhibited multi-organ inflammation, increased cytokine production, global T cell activation, activation of antigen-presenting cells and B cell developmental defects, all features that are shared with mice completely deficient in FOXP3. Our results demonstrate that the mouse counterpart of human FOXP3Δ2Δ7 is unable to confer suppressive ability to Treg cells.
AB - The forkhead/winged-helix transcription factor FOXP3 confers suppressive ability to CD4(+)FOXP3(+) regulatory T (Treg) cells. Human Treg cells express several different isoforms of FOXP3 that differ in function. However, the regulation and functional consequences of FOXP3 isoform expression remains poorly understood. In order to study the function of the FOXP3Δ2Δ7 isoform in vivo we generated mice that exclusively expressed a Foxp3 isoform lacking exon 2 and 7. These mice exhibited multi-organ inflammation, increased cytokine production, global T cell activation, activation of antigen-presenting cells and B cell developmental defects, all features that are shared with mice completely deficient in FOXP3. Our results demonstrate that the mouse counterpart of human FOXP3Δ2Δ7 is unable to confer suppressive ability to Treg cells.
KW - Animals
KW - Exons
KW - Forkhead Transcription Factors
KW - Humans
KW - Lymphocyte Activation
KW - Mice
KW - Mice, Transgenic
KW - Protein Isoforms
KW - T-Lymphocytes, Regulatory
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.jaut.2015.06.009
DO - 10.1016/j.jaut.2015.06.009
M3 - SCORING: Journal article
C2 - 26149776
VL - 63
SP - 23
EP - 30
JO - J AUTOIMMUN
JF - J AUTOIMMUN
SN - 0896-8411
ER -