Follow-up survey of children who received sulfadoxine-pyrimethamine for intermittent preventive antimalarial treatment in infants
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Follow-up survey of children who received sulfadoxine-pyrimethamine for intermittent preventive antimalarial treatment in infants. / Kobbe, Robin; Hogan, Benedikt; Adjei, Samuel; Klein, Philipp; Kreuels, Benno; Loag, Wibke; Adjei, Ohene; May, Jürgen.
In: J INFECT DIS, Vol. 203, No. 4, 15.02.2011, p. 556-60.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Follow-up survey of children who received sulfadoxine-pyrimethamine for intermittent preventive antimalarial treatment in infants
AU - Kobbe, Robin
AU - Hogan, Benedikt
AU - Adjei, Samuel
AU - Klein, Philipp
AU - Kreuels, Benno
AU - Loag, Wibke
AU - Adjei, Ohene
AU - May, Jürgen
PY - 2011/2/15
Y1 - 2011/2/15
N2 - Recently, the World Health Organization emphasized the potential benefit of intermittent preventive treatment in infants (IPTi) to control malaria and officially recommended implementation of IPTi with sulfadoxine-pyrimethamine (SP) in areas with moderate and high transmission, where SP resistance is not high. As reported rebound effects make further observation mandatory, we performed a survey of participants of a former IPTi trial. Malariometric parameters were similar in the SP and the placebo group. In contrast, anti-Plasmodium falciparum lysate immunoglobulin G antibody levels, a proxy measure for preceding malaria episodes, remained lower in the SP arm. The most likely explanation is a lower overall exposure to parasitic antigens after IPTi.
AB - Recently, the World Health Organization emphasized the potential benefit of intermittent preventive treatment in infants (IPTi) to control malaria and officially recommended implementation of IPTi with sulfadoxine-pyrimethamine (SP) in areas with moderate and high transmission, where SP resistance is not high. As reported rebound effects make further observation mandatory, we performed a survey of participants of a former IPTi trial. Malariometric parameters were similar in the SP and the placebo group. In contrast, anti-Plasmodium falciparum lysate immunoglobulin G antibody levels, a proxy measure for preceding malaria episodes, remained lower in the SP arm. The most likely explanation is a lower overall exposure to parasitic antigens after IPTi.
KW - Antibodies, Protozoan
KW - Antimalarials
KW - Chemoprevention
KW - Child, Preschool
KW - Drug Combinations
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Immunoglobulin G
KW - Infant
KW - Malaria, Falciparum
KW - Male
KW - Plasmodium falciparum
KW - Pyrimethamine
KW - Seroepidemiologic Studies
KW - Sulfadoxine
U2 - 10.1093/infdis/jiq079
DO - 10.1093/infdis/jiq079
M3 - SCORING: Journal article
C2 - 21248056
VL - 203
SP - 556
EP - 560
JO - J INFECT DIS
JF - J INFECT DIS
SN - 0022-1899
IS - 4
ER -