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Follow-up survey of children who received sulfadoxine-pyrimethamine for intermittent preventive antimalarial treatment in infants

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Follow-up survey of children who received sulfadoxine-pyrimethamine for intermittent preventive antimalarial treatment in infants. / Kobbe, Robin; Hogan, Benedikt; Adjei, Samuel; Klein, Philipp; Kreuels, Benno; Loag, Wibke; Adjei, Ohene; May, Jürgen.

in: J INFECT DIS, Jahrgang 203, Nr. 4, 15.02.2011, S. 556-60.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kobbe, R, Hogan, B, Adjei, S, Klein, P, Kreuels, B, Loag, W, Adjei, O & May, J 2011, 'Follow-up survey of children who received sulfadoxine-pyrimethamine for intermittent preventive antimalarial treatment in infants', J INFECT DIS, Jg. 203, Nr. 4, S. 556-60. https://doi.org/10.1093/infdis/jiq079

APA

Kobbe, R., Hogan, B., Adjei, S., Klein, P., Kreuels, B., Loag, W., Adjei, O., & May, J. (2011). Follow-up survey of children who received sulfadoxine-pyrimethamine for intermittent preventive antimalarial treatment in infants. J INFECT DIS, 203(4), 556-60. https://doi.org/10.1093/infdis/jiq079

Vancouver

Kobbe R, Hogan B, Adjei S, Klein P, Kreuels B, Loag W et al. Follow-up survey of children who received sulfadoxine-pyrimethamine for intermittent preventive antimalarial treatment in infants. J INFECT DIS. 2011 Feb 15;203(4):556-60. https://doi.org/10.1093/infdis/jiq079

Bibtex

@article{06be62e105844157b564f9af360eacfc,
title = "Follow-up survey of children who received sulfadoxine-pyrimethamine for intermittent preventive antimalarial treatment in infants",
abstract = "Recently, the World Health Organization emphasized the potential benefit of intermittent preventive treatment in infants (IPTi) to control malaria and officially recommended implementation of IPTi with sulfadoxine-pyrimethamine (SP) in areas with moderate and high transmission, where SP resistance is not high. As reported rebound effects make further observation mandatory, we performed a survey of participants of a former IPTi trial. Malariometric parameters were similar in the SP and the placebo group. In contrast, anti-Plasmodium falciparum lysate immunoglobulin G antibody levels, a proxy measure for preceding malaria episodes, remained lower in the SP arm. The most likely explanation is a lower overall exposure to parasitic antigens after IPTi.",
keywords = "Antibodies, Protozoan, Antimalarials, Chemoprevention, Child, Preschool, Drug Combinations, Female, Follow-Up Studies, Humans, Immunoglobulin G, Infant, Malaria, Falciparum, Male, Plasmodium falciparum, Pyrimethamine, Seroepidemiologic Studies, Sulfadoxine",
author = "Robin Kobbe and Benedikt Hogan and Samuel Adjei and Philipp Klein and Benno Kreuels and Wibke Loag and Ohene Adjei and J{\"u}rgen May",
year = "2011",
month = feb,
day = "15",
doi = "10.1093/infdis/jiq079",
language = "English",
volume = "203",
pages = "556--60",
journal = "J INFECT DIS",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Follow-up survey of children who received sulfadoxine-pyrimethamine for intermittent preventive antimalarial treatment in infants

AU - Kobbe, Robin

AU - Hogan, Benedikt

AU - Adjei, Samuel

AU - Klein, Philipp

AU - Kreuels, Benno

AU - Loag, Wibke

AU - Adjei, Ohene

AU - May, Jürgen

PY - 2011/2/15

Y1 - 2011/2/15

N2 - Recently, the World Health Organization emphasized the potential benefit of intermittent preventive treatment in infants (IPTi) to control malaria and officially recommended implementation of IPTi with sulfadoxine-pyrimethamine (SP) in areas with moderate and high transmission, where SP resistance is not high. As reported rebound effects make further observation mandatory, we performed a survey of participants of a former IPTi trial. Malariometric parameters were similar in the SP and the placebo group. In contrast, anti-Plasmodium falciparum lysate immunoglobulin G antibody levels, a proxy measure for preceding malaria episodes, remained lower in the SP arm. The most likely explanation is a lower overall exposure to parasitic antigens after IPTi.

AB - Recently, the World Health Organization emphasized the potential benefit of intermittent preventive treatment in infants (IPTi) to control malaria and officially recommended implementation of IPTi with sulfadoxine-pyrimethamine (SP) in areas with moderate and high transmission, where SP resistance is not high. As reported rebound effects make further observation mandatory, we performed a survey of participants of a former IPTi trial. Malariometric parameters were similar in the SP and the placebo group. In contrast, anti-Plasmodium falciparum lysate immunoglobulin G antibody levels, a proxy measure for preceding malaria episodes, remained lower in the SP arm. The most likely explanation is a lower overall exposure to parasitic antigens after IPTi.

KW - Antibodies, Protozoan

KW - Antimalarials

KW - Chemoprevention

KW - Child, Preschool

KW - Drug Combinations

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Immunoglobulin G

KW - Infant

KW - Malaria, Falciparum

KW - Male

KW - Plasmodium falciparum

KW - Pyrimethamine

KW - Seroepidemiologic Studies

KW - Sulfadoxine

U2 - 10.1093/infdis/jiq079

DO - 10.1093/infdis/jiq079

M3 - SCORING: Journal article

C2 - 21248056

VL - 203

SP - 556

EP - 560

JO - J INFECT DIS

JF - J INFECT DIS

SN - 0022-1899

IS - 4

ER -