Fluorescence-guided bone resection in bisphosphonate-associated osteonecrosis of the jaws
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Fluorescence-guided bone resection in bisphosphonate-associated osteonecrosis of the jaws. / Pautke, Christoph; Bauer, Florian; Tischer, Thomas; Kreutzer, Kilian; Weitz, Jochen; Kesting, Marco; Hölzle, Frank; Kolk, Andreas; Stürzenbaum, Stephen R; Wolff, Klaus-Dietrich.
In: J ORAL MAXIL SURG, Vol. 67, No. 3, 03.2009, p. 471-6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Fluorescence-guided bone resection in bisphosphonate-associated osteonecrosis of the jaws
AU - Pautke, Christoph
AU - Bauer, Florian
AU - Tischer, Thomas
AU - Kreutzer, Kilian
AU - Weitz, Jochen
AU - Kesting, Marco
AU - Hölzle, Frank
AU - Kolk, Andreas
AU - Stürzenbaum, Stephen R
AU - Wolff, Klaus-Dietrich
PY - 2009/3
Y1 - 2009/3
N2 - PURPOSE: To date, the therapy of bisphosphonate-associated osteonecrosis of the jaws (BONJ) has been hampered by the lack of imaging modalities that enable the extent of necrosis to be visualized. This study aims to demonstrate the feasibility of tetracycline fluorescence guided bone resection in the surgical management of BONJ.PATIENTS AND METHODS: Following a 10-day preoperative administration of doxycycline in patients suffering from BONJ, sufficient doxycycline is incorporated into viable bone to be visualized with a certified medical lamp emitting exciting light at 400 to 460 nm.RESULTS: Viable and necrotic bone can be discriminated intraoperatively in a routine and reproducible manner by doxycycline bone fluorescence.CONCLUSION: In the therapy of BONJ, conservative concepts are to be favored. The fact that necrotic bone can now be selectively resected signifies an improvement of the conservative surgical therapy of BONJ.
AB - PURPOSE: To date, the therapy of bisphosphonate-associated osteonecrosis of the jaws (BONJ) has been hampered by the lack of imaging modalities that enable the extent of necrosis to be visualized. This study aims to demonstrate the feasibility of tetracycline fluorescence guided bone resection in the surgical management of BONJ.PATIENTS AND METHODS: Following a 10-day preoperative administration of doxycycline in patients suffering from BONJ, sufficient doxycycline is incorporated into viable bone to be visualized with a certified medical lamp emitting exciting light at 400 to 460 nm.RESULTS: Viable and necrotic bone can be discriminated intraoperatively in a routine and reproducible manner by doxycycline bone fluorescence.CONCLUSION: In the therapy of BONJ, conservative concepts are to be favored. The fact that necrotic bone can now be selectively resected signifies an improvement of the conservative surgical therapy of BONJ.
KW - Aged
KW - Bone Density Conservation Agents
KW - Cone-Beam Computed Tomography
KW - Diphosphonates
KW - Feasibility Studies
KW - Female
KW - Fluorescence
KW - Fluorometry
KW - Humans
KW - Jaw
KW - Jaw Diseases
KW - Light
KW - Male
KW - Oral Surgical Procedures
KW - Osteonecrosis
KW - Tetracycline
U2 - 10.1016/j.joms.2008.09.037
DO - 10.1016/j.joms.2008.09.037
M3 - SCORING: Journal article
C2 - 19231768
VL - 67
SP - 471
EP - 476
JO - J ORAL MAXIL SURG
JF - J ORAL MAXIL SURG
SN - 0278-2391
IS - 3
ER -