First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia.
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First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia. / Peinemann, Frank; Grouven, Ulrich; Kröger, Nicolaus; Bartel, Carmen; Pittler, Max H; Lange, Stefan.
In: PLOS ONE, Vol. 6, No. 4, 4, 2011, p. 18572.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia.
AU - Peinemann, Frank
AU - Grouven, Ulrich
AU - Kröger, Nicolaus
AU - Bartel, Carmen
AU - Pittler, Max H
AU - Lange, Stefan
PY - 2011
Y1 - 2011
N2 - Acquired severe aplastic anemia (SAA) is a rare and progressive disease characterized by an immune-mediated functional impairment of hematopoietic stem cells. Transplantation of these cells is a first-line treatment option if HLA-matched related donors are available. First-line immunosuppressive therapy may be offered as alternative. The aim was to compare the outcome of these patients in controlled trials.
AB - Acquired severe aplastic anemia (SAA) is a rare and progressive disease characterized by an immune-mediated functional impairment of hematopoietic stem cells. Transplantation of these cells is a first-line treatment option if HLA-matched related donors are available. First-line immunosuppressive therapy may be offered as alternative. The aim was to compare the outcome of these patients in controlled trials.
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - Treatment Outcome
KW - Survival Analysis
KW - Publication Bias
KW - Tissue Donors
KW - Anemia, Aplastic/drug therapy/mortality
KW - Graft vs Host Disease/chemically induced/etiology
KW - Hematopoietic Stem Cell Transplantation/adverse effects
KW - Histocompatibility Testing
KW - Immunosuppressive Agents/adverse effects/therapeutic use
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - Treatment Outcome
KW - Survival Analysis
KW - Publication Bias
KW - Tissue Donors
KW - Anemia, Aplastic/drug therapy/mortality
KW - Graft vs Host Disease/chemically induced/etiology
KW - Hematopoietic Stem Cell Transplantation/adverse effects
KW - Histocompatibility Testing
KW - Immunosuppressive Agents/adverse effects/therapeutic use
U2 - 10.1371/journal.pone.0018572
DO - 10.1371/journal.pone.0018572
M3 - SCORING: Journal article
VL - 6
SP - 18572
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 4
M1 - 4
ER -