First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia.

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First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia. / Peinemann, Frank; Grouven, Ulrich; Kröger, Nicolaus; Bartel, Carmen; Pittler, Max H; Lange, Stefan.

in: PLOS ONE, Jahrgang 6, Nr. 4, 4, 2011, S. 18572.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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@article{481e3b35192446b8bd4e9e8992e73aa9,
title = "First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia.",
abstract = "Acquired severe aplastic anemia (SAA) is a rare and progressive disease characterized by an immune-mediated functional impairment of hematopoietic stem cells. Transplantation of these cells is a first-line treatment option if HLA-matched related donors are available. First-line immunosuppressive therapy may be offered as alternative. The aim was to compare the outcome of these patients in controlled trials.",
keywords = "Adult, Humans, Male, Aged, Female, Middle Aged, Adolescent, Young Adult, Treatment Outcome, Survival Analysis, Publication Bias, *Tissue Donors, Anemia, Aplastic/*drug therapy/mortality, Graft vs Host Disease/chemically induced/etiology, *Hematopoietic Stem Cell Transplantation/adverse effects, *Histocompatibility Testing, Immunosuppressive Agents/adverse effects/*therapeutic use, Adult, Humans, Male, Aged, Female, Middle Aged, Adolescent, Young Adult, Treatment Outcome, Survival Analysis, Publication Bias, *Tissue Donors, Anemia, Aplastic/*drug therapy/mortality, Graft vs Host Disease/chemically induced/etiology, *Hematopoietic Stem Cell Transplantation/adverse effects, *Histocompatibility Testing, Immunosuppressive Agents/adverse effects/*therapeutic use",
author = "Frank Peinemann and Ulrich Grouven and Nicolaus Kr{\"o}ger and Carmen Bartel and Pittler, {Max H} and Stefan Lange",
year = "2011",
doi = "10.1371/journal.pone.0018572",
language = "English",
volume = "6",
pages = "18572",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

RIS

TY - JOUR

T1 - First-line matched related donor hematopoietic stem cell transplantation compared to immunosuppressive therapy in acquired severe aplastic anemia.

AU - Peinemann, Frank

AU - Grouven, Ulrich

AU - Kröger, Nicolaus

AU - Bartel, Carmen

AU - Pittler, Max H

AU - Lange, Stefan

PY - 2011

Y1 - 2011

N2 - Acquired severe aplastic anemia (SAA) is a rare and progressive disease characterized by an immune-mediated functional impairment of hematopoietic stem cells. Transplantation of these cells is a first-line treatment option if HLA-matched related donors are available. First-line immunosuppressive therapy may be offered as alternative. The aim was to compare the outcome of these patients in controlled trials.

AB - Acquired severe aplastic anemia (SAA) is a rare and progressive disease characterized by an immune-mediated functional impairment of hematopoietic stem cells. Transplantation of these cells is a first-line treatment option if HLA-matched related donors are available. First-line immunosuppressive therapy may be offered as alternative. The aim was to compare the outcome of these patients in controlled trials.

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Adolescent

KW - Young Adult

KW - Treatment Outcome

KW - Survival Analysis

KW - Publication Bias

KW - Tissue Donors

KW - Anemia, Aplastic/drug therapy/mortality

KW - Graft vs Host Disease/chemically induced/etiology

KW - Hematopoietic Stem Cell Transplantation/adverse effects

KW - Histocompatibility Testing

KW - Immunosuppressive Agents/adverse effects/therapeutic use

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Adolescent

KW - Young Adult

KW - Treatment Outcome

KW - Survival Analysis

KW - Publication Bias

KW - Tissue Donors

KW - Anemia, Aplastic/drug therapy/mortality

KW - Graft vs Host Disease/chemically induced/etiology

KW - Hematopoietic Stem Cell Transplantation/adverse effects

KW - Histocompatibility Testing

KW - Immunosuppressive Agents/adverse effects/therapeutic use

U2 - 10.1371/journal.pone.0018572

DO - 10.1371/journal.pone.0018572

M3 - SCORING: Journal article

VL - 6

SP - 18572

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 4

M1 - 4

ER -